5-HT2C Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS1116

Novus Biologicals, part of Bio-Techne
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NLS1116
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Key Product Details

Species Reactivity

Validated:

Human, Monkey, Primate

Predicted:

Chimpanzee (100%), Equine (94%), Orangutan (100%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1.0 mg/ml

View all 5-HT2C Antibodies »

Product Specifications

Immunogen

Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human 5-HT2C.

Epitope

3rd cytoplasmic domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Marmoset (100%), Bat (81%), Rabbit (81%).

Specificity

Human 5-HT2C. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for 5-HT2C Antibody - BSA Free

Immunohistochemistry-Paraffin: 5-HT2C Antibody - BSA Free [NLS1116]

Immunohistochemistry-Paraffin: 5-HT2C Antibody - BSA Free [NLS1116]

Immunohistochemistry-Paraffin: 5-HT2C Antibody [NLS1116] - Analysis of anti-5HT2C Receptor antibody with human pancreas, ganglion and Schwann cells.

Applications for 5-HT2C Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

2.6 ug/ml
Application Notes
.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: 5-HT2C

5-HT2C, a Serotonin Receptor previously termed 5-HT1C, activates phospholipase C, resulting in a transient increase in intracellular calcium and activation of protein kinase C. Mutant mice lacking functional 5-HT2C receptor are overweight due to abnormal feeding behavior and are prone to epileptic seizures. Therefore, agonists of the 5-HT2C receptor such as m-chlorophenylpiperazine (mCPP) may be potential drugs for the treatment of obesity. However, mCPP also has unpleasant side effects such as anxiety and nausea in humans. Most psychedelic drugs bind 5-HT2A and 5-HT2C receptors, and their hallucinogenicity correlates with binding affinity. Expression of the 5-HT2C receptor has been reported predominantly in brain, but also in spinal cord and lung. ESTs have been isolated from human, mouse, and rat brain libraries.

Long Name

5-Hydroxytryptamine Receptor 2C

Alternate Names

5-HTR2C, 5HT2C, HTR2C, Serotonin Receptor 2C

Entrez Gene IDs

3358 (Human)

Gene Symbol

HTR2C

Additional 5-HT2C Products

Product Documents for 5-HT2C Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for 5-HT2C Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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