5-HT6 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-32079

Novus Biologicals, part of Bio-Techne
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NBP2-32079
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

View all 5-HT6 Antibodies »

Product Summary for 5-HT6 Antibody

Immunogen

The immunogen this antibody was made to, maps to a region between residue 1 to 50 of human 5-Hydroxytryptamine Receptor 6 using the numbering given in entry NP_000862.1 (GeneID 3362).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for 5-HT6 Antibody

Immunoprecipitation: 5-HT6 Antibody [NBP2-32079]

Immunoprecipitation: 5-HT6 Antibody [NBP2-32079]

Immunoprecipitation: 5-HT6 Antibody [NBP2-32079] - Samples: Whole cell lysate (0.5 or 1.0 mg per IP reaction; 20% of IP loaded) prepared using RIPA buffer from Jurkat cells. Antibodies: Affinity purified rabbit anti-5-HT6 antibody NBP2-32079 used for IP at 6 ug per reaction. 5-HT6 was also immunoprecipitated by rabbit anti-5-HT6 antibody BL16176. For blotting immunoprecipitated 5-HT6, NBP2-32079 was used at 1 ug/ml. Detection: Chemiluminescence with an exposure time of 30 seconds.

Applications for 5-HT6 Antibody

Application
Recommended Usage

Immunoprecipitation

2 - 10 ug/mg lysate
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris-Citrate/Phosphate (pH 7.0 - 8.0)

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: 5-HT6

5-HT6, a Serotonin Receptor, appears to regulate cholinergic neurotransmission in the brain rather than the expected interaction as a modulator of dopaminergic transmission. This interaction predicts a possible role for 5-HT6 Receptor antagonists in the treatment of learning and memory disorders. The 5-HT6 Receptor is abundant in limbic areas, which participate in the control of mood and emotion. Some antidepressants and antipsychotics are potent 5-HT6 Receptor antagonists, making this gene valuable for the pharmaceutical industry. 5-HT6 may be involved in the pathogenesis of mood disorders, schizophrenia, in Alzheimer's disease. A splice variant that has a 289bp deletion in the transmembrane region IV and the third intracellular loop has been isolated. 5-HT6 Receptor has been reported primarily in striatum of the brain. Expression has also been seen in stomach, spinal cord, and the lymphoid tissues of rats, including peripheral blood lymphocytes, spleen, and thymus. ESTs have been isolated from brain libraries.

Long Name

5-Hydroxytryptamine Receptor 6

Alternate Names

HTR6

Gene Symbol

HTR6

UniProt

NP_000862.1 (Human)

Additional 5-HT6 Products

Product Documents for 5-HT6 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for 5-HT6 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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