Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61471

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM232

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Acetyl-CoA Carboxylase alpha/ACACA Antibodies »

Product Specifications

Immunogen

A peptide corresponding to Human Acetyl-CoA Carboxylase alpha/ACACA

Reactivity Notes

This antibody may also react to mouse or rat Acetyl-CoA Carboxylase alpha/ACACA, as predicted by immunogen homology.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232)

Western Blot: Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232) [NBP2-61471] -

Western Blot: Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232) [NBP2-61471] - Western Blot of A431 cell lysates using NBP2-61471 at a 1:1000 dilution, showed a band of Acetyl CoA Carboxylase 1 (~260 kDa) expressed in A431 cells.

Immunohistochemistry-Paraffin: Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232) [NBP2-61471] -

Immunohistochemistry-Paraffin: Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232) [NBP2-61471] - Immunohistochemical staining of formalin fixed and paraffin embedded Human heart tissue sections using NBP2-61471 at a 1:300 dilution.

Applications for Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232)

Application
Recommended Usage

Immunohistochemistry

1:300 - 1:500

Western Blot

1:1000-1:2000

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Acetyl-CoA Carboxylase alpha/ACACA

Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Long Name

Acetyl-Coenzyme A Carboxylase alpha

Alternate Names

ACACA, ACC1, ACCA, AcetylCoA Carboxylase alpha

Gene Symbol

ACACA

Additional Acetyl-CoA Carboxylase alpha/ACACA Products

Product Documents for Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Acetyl-CoA Carboxylase alpha/ACACA Antibody (RM232)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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