Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61473

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Biological Validation

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM270

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Acetyl-CoA Carboxylase alpha/ACACA Antibodies »

Product Summary for Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270)

Immunogen

A phospho-peptide corresponding to Human Acetyl-CoA Carboxylase alpha/ACACA [p Ser79]

Modification

p Ser79

Specificity

This antibody reacts to human Acetyl-CoA Carboxylase alpha/ACACA only when phosphorylated at Ser79. There is no cross-reactivity to Acetyl-CoA Carboxylase alpha/ACACA without phosphorylation at Ser79.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270)

Western Blot: Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270) [NBP2-61473] -

Western Blot: Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270) [NBP2-61473] - Western Blot of A431 cell lysates, nontreated (-) or treated (+) with Lambda Protein Phosphatase (lPP), using NBP2-61473 at a 1:1000 dilution.

Immunohistochemistry-Paraffin: Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270) [NBP2-61473] -

Immunohistochemistry-Paraffin: Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270) [NBP2-61473] - Immunohistochemical staining of formalin fixed and paraffin embedded Human breast cancer tissue sections using NBP2-61473 at a 1:5000 dilution

Applications for Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270)

Application
Recommended Usage

Immunohistochemistry

1:1000-1:2000

Western Blot

1:1000 - 1:5000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Acetyl-CoA Carboxylase alpha/ACACA

Acetyl-CoA carboxylase 1 (ACC1) is a biotin dependent lipogenic enzyme that is highly expressed during adipogenesis. ACC1 catalyzes acetyl-CoA carboxylation, producing malonyl-CoA, a metabolite involved in energy homeostasis regulation. Malonyl-CoA is a two carbon donor in the synthesis of long-chain fatty acids and the elongation of fatty acids found in the cystol (1). ACC1 is regulated short-term by citrate, CoA, and palmitoyl-CoA through allosteric interactions. Nutrients and hormones can be both short-term (inducing reversible phosphorylations by such as AMPK) and long-term (transcription level regulation) regulators of ACC1 (2). Highly expressed in lipogenic tissues, ACC1 is found in liver, adipose, and lactating mammary gland (3). ACC1 has been implicated as a target in the development of anti-obesity drugs (4).

Long Name

Acetyl-Coenzyme A Carboxylase alpha

Alternate Names

ACACA, ACC1, ACCA, AcetylCoA Carboxylase alpha

Gene Symbol

ACACA

Additional Acetyl-CoA Carboxylase alpha/ACACA Products

Product Documents for Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Acetyl-CoA Carboxylase alpha/ACACA [p Ser79] Antibody (RM270)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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