Activin RIIB Antibody (7B10)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15231

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15231
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Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 7B10

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

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Product Summary for Activin RIIB Antibody (7B10)

Immunogen

A synthesized peptide derived from human Activin RIIB. UniProt ID (Q13705).

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Activin RIIB Antibody (7B10)

Immunohistochemistry: Activin RIIB Antibody (7B10) [NBP3-15231]

Immunohistochemistry: Activin RIIB Antibody (7B10) [NBP3-15231]

Immunohistochemistry: Activin RIIB Antibody (7B10) [NBP3-15231] - IHC image of Activin RIIB antibody diluted at 1:100 and staining in paraffin-embedded human breast cancer. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
Immunohistochemistry: Activin RIIB Antibody (7B10) [NBP3-15231]

Immunohistochemistry: Activin RIIB Antibody (7B10) [NBP3-15231]

Immunohistochemistry: Activin RIIB Antibody (7B10) [NBP3-15231] - IHC image of Activin RIIB antibody diluted at 1:100 and staining in paraffin-embedded human placenta tissue. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30 minutes at RT. Then primary antibody (1% BSA) was incubated at 4C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Applications for Activin RIIB Antibody (7B10)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.4), 150mM NaCl, and 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -80C. Avoid freeze-thaw cycles.

Background: Activin RIIB

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq]

Long Name

Activin Receptor IIB

Alternate Names

ActivinRIIB, ACVR2B

Gene Symbol

ACVR2B

Additional Activin RIIB Products

Product Documents for Activin RIIB Antibody (7B10)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Activin RIIB Antibody (7B10)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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