AGTR-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-59006

Novus Biologicals, part of Bio-Techne
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NBP1-59006
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Key Product Details

Species Reactivity

Human, Mouse

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all AGTR-1 Antibodies »

Product Specifications

Immunogen

Synthetic peptides corresponding to AGTR1(angiotensin II receptor, type 1) The peptide sequence was selected from the N terminal of AGTR1 (NP_004826). Peptide sequence ILNSSTEDGIKRIQDDCPKAGRHNYIFVMIPTLYSIIFVVGIFGNSLVVI. The peptide sequence for this immunogen was taken from within the described region.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

41 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Description

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Scientific Data Images for AGTR-1 Antibody

Western Blot: AGTR-1 Antibody [NBP1-59006]

Western Blot: AGTR-1 Antibody [NBP1-59006]

Western Blot: AGTR-1 Antibody [NBP1-59006] - Mouse Brain Membranes at 1:4000.
Western Blot: AGTR-1 Antibody [NBP1-59006]

Western Blot: AGTR-1 Antibody [NBP1-59006]

Western Blot: AGTR-1 Antibody [NBP1-59006] - Human fetal heart tissue lysate at a concentration of 1ug/ml.

Applications for AGTR-1 Antibody

Application
Recommended Usage

Western Blot

1.0 ug/ml

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, 2% Sucrose

Preservative

0.09% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: AGTR-1

Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. AGTR1 is the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. AGTR1 may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans.Angiotensin II is a potent vasopressor hormone and a primary regulator of aldosterone secretion. It is an important effector controlling blood pressure and volume in the cardiovascular system. It acts through at least two types of receptors. This gene encodes the type 1 receptor which is thought to mediate the major cardiovascular effects of angiotensin II. This gene may play a role in the generation of reperfusion arrhythmias following restoration of blood flow to ischemic or infarcted myocardium. It was previously thought that a related gene, denoted as AGTR1B, existed; however, it is now believed that there is only one type 1 receptor gene in humans. At least five transcript variants have been described for this gene. Additional variants have been described but their full-length nature has not been determined. The entire coding sequence is contained in the terminal exon and is present in all transcript variants.

Long Name

Angiotensin II Receptor Type 1

Alternate Names

AG2S, AGTR1, AT1, AT1AR, AT1BR, AT1R, AT2R1

Entrez Gene IDs

185 (Human)

Gene Symbol

AGTR1

UniProt

P30556 (Human)

Additional AGTR-1 Products

Product Documents for AGTR-1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for AGTR-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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