Aiolos/IKZF3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-89185

Novus Biologicals, part of Bio-Techne
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NBP1-89185-25ul
NBP1-89185
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Aiolos/IKZF3 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: AVLNDYSLTKSHEMENVDSGEGPANEDEDIGDDSMKVKDEYSERDENVLKSEPMGNAEEPEIPYSYSREYNEYENIKLERHVVSFDSSRPTSGKMNCDVCGLSCISFNVL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Aiolos/IKZF3 Antibody

Immunocytochemistry/ Immunofluorescence: Aiolos/IKZF3 Antibody [NBP1-89185]

Immunocytochemistry/ Immunofluorescence: Aiolos/IKZF3 Antibody [NBP1-89185]

Immunocytochemistry/Immunofluorescence: Aiolos/IKZF3 Antibody [NBP1-89185] - Staining of human cell line U-251 MG shows localization to plasma membrane and cytosol. Antibody staining is shown in green.
Immunohistochemistry-Paraffin: Aiolos/IKZF3 Antibody [NBP1-89185]

Immunohistochemistry-Paraffin: Aiolos/IKZF3 Antibody [NBP1-89185]

Immunohistochemistry-Paraffin: Aiolos/IKZF3 Antibody [NBP1-89185] - Staining in human tonsil and cerebral cortex tissues using anti-IKZF3 antibody. Corresponding IKZF3 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Aiolos/IKZF3 Antibody [NBP1-89185]

Immunohistochemistry-Paraffin: Aiolos/IKZF3 Antibody [NBP1-89185]

Immunohistochemistry-Paraffin: Aiolos/IKZF3 Antibody [NBP1-89185] - Staining of human tonsil shows distinct nuclear positivity in most cells.
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Applications for Aiolos/IKZF3 Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended. ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Aiolos/IKZF3

IKZF3 encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described. [provided by RefSeq]

Long Name

DNA-binding Protein Aiolos

Alternate Names

AIO, IKZF3, ZNFN1A3

Gene Symbol

IKZF3

Additional Aiolos/IKZF3 Products

Product Documents for Aiolos/IKZF3 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Aiolos/IKZF3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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