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Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-32015

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-32015

Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # JE36-28

Concentration

1 mg/ml

Product Summary for Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

Immunogen

Recombinant protein. (Uniprot: P42330)

Localization

Cytoplasm.

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

37 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

Western Blot: Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28) [NBP3-32015]

Western Blot: Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28) [NBP3-32015] - Western blot analysis of Aldo-keto Reductase 1C3/AKR1C3 on different lysates with Rabbit anti-Aldo-keto Reductase 1C3/AKR1C3 antibody (NBP3-32015) at 1/1,000 dilution.

Lane 1: A549 cell lysate (20 ug/Lane)
Lane 2: HepG2 cell lysate (20 ug/Lane)
Lane 3: K-562 cell lysate (20 ug/Lane)
Lane 4: Human kidney tissue lysate (40 ug/Lane)
Lane 5: Mouse kidney tissue lysate (40 ug/Lane)
Lane 6: Rat kidney tissue lysate (40 ug/Lane)

Predicted band size: 37 kDa
Observed band size: 35 kDa

Exposure time: 20 seconds; ECL;

4-20% SDS-PAGE gel.

Proteins were transferred to a PVDF membrane and blocked with 5% NFDM/TBST for 1 hour at room temperature. The primary antibody (NBP3-32015) at 1/1,000 dilution was used in 5% NFDM/TBST at 4℃ overnight. Goat Anti-Rabbit IgG - HRP Secondary Antibody at 1/50,000 dilution was used for 1 hour at room temperature.

Applications for Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

Application
Recommended Usage

Western Blot

1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

1*TBS (pH7.4), 0.05% BSA and 40% Glycerol

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Aldo-keto Reductase 1C3/AKR1C3

AKR1C3 encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ), and the oxidation of 9alpha,11beta-PGF2 to PGD2. It may play an important role in the pathogenesis of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.

Long Name

Aldo-keto Reductase Family 1, Member C3

Alternate Names

AKR1C3, AldoketoReductase 1C3, DD3, DDX, HA1753, HAKRB, HSD17B5, PGFS

Gene Symbol

AKR1C3

Additional Aldo-keto Reductase 1C3/AKR1C3 Products

Product Documents for Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Aldo-keto Reductase 1C3/AKR1C3 Antibody (JE36-28)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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