AMPK alpha 1 Antibody (RM301)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61491

Recombinant Monoclonal Antibody.
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # RM301

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all AMPK alpha 1 Antibodies »

Product Summary for AMPK alpha 1 Antibody (RM301)

Immunogen

A peptide corresponding to the residues near the C-terminus of Human AMPK alpha 1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for AMPK alpha 1 Antibody (RM301)

Western Blot: AMPK alpha 1 Antibody (RM301) [NBP2-61491] -

Western Blot: AMPK alpha 1 Antibody (RM301) [NBP2-61491] - Western Blot of HeLa cells lysate using NBP2-61491 at a 1:100 dilution

Immunohistochemistry: AMPK alpha 1 Antibody (RM301) [NBP2-61491] -

Immunohistochemistry: AMPK alpha 1 Antibody (RM301) [NBP2-61491] - Immunohistochemical staining of formalin fixed and paraffin embedded human colon tissue section using NBP2-61491 at a 1:200 dilution

Applications for AMPK alpha 1 Antibody (RM301)

Application
Recommended Usage

Immunohistochemistry

1:100-1:200

Western Blot

1:100 - 1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

50% Glycerol/PBS, 1% BSA

Preservative

0.09% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: AMPK alpha 1

The 5'-AMP-activated protein kinase (AMPK), a member of the SNF1 (sucrose non-fermentor) kinase family (1) AMPK is a heterotrimeric protein comprising alpha (63 kDa), beta (38 kDa) and gamma (38 kDa) subunits. The alpha subunit is the catalytic subunit (which requires phosphorylation to be active) (2-3). Beta and gamma are non-catalytic subunits, although they have been found to interact with the active subunit in liver. AMPK regulates fatty acid and sterol synthesis by phosphorylation of acetyl-CoA as well as cholesterol synthesis via phosphorylation and inactivation of hydroxymethylglutaryl-CoA reductase (4). AMPK also appears to play a role in protecting cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways

Long Name

AMP-activated Protein Kinase alpha 1

Alternate Names

PRKAA1

Gene Symbol

PRKAA1

Additional AMPK alpha 1 Products

Product Documents for AMPK alpha 1 Antibody (RM301)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for AMPK alpha 1 Antibody (RM301)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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