Androgen R/NR3C4 Antibody (CL9255)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-88922

Novus Biologicals, part of Bio-Techne
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # CL9255

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Androgen R/NR3C4 Antibodies »

Product Specifications

Immunogen

This antibody was developed against a synthetic peptide corresponding to amino acids: GEDGSPQAHRRGPTGYLVLDEE

Reactivity Notes

Mouse (86%), Rat (81%).

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Scientific Data Images for Androgen R/NR3C4 Antibody (CL9255)

Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922]

Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922]

Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922] - Analysis in human fallopian tube and cerebral cortex tissues using NBP2-88922 antibody. Corresponding AR RNA-seq data are presented for the same tissues.
Western Blot: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922]

Western Blot: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922]

Western Blot: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922] - Analysis in human cell line RH-30.
Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922]

Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922]

Immunohistochemistry-Paraffin: Androgen R/NR3C4 Antibody (CL9255) [NBP2-88922] - Staining of human breast cancer shows strong nuclear positivity in tumor cells.
View 4 more images

Applications for Androgen R/NR3C4 Antibody (CL9255)

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000 - 1:2500

Western Blot

1 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS, pH 7.2, containing 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Androgen R/NR3C4

Androgens have a broad range of effects on the appearance and maintenance of male secondary sexual characteristics. Like other members of the steroid superfamily, the androgen receptor (AR) consists of an amino terminal modulating domain, a central DNA binding domain, a hinge region and a carboxy terminal ligand binding domain. The androgen receptor (AR) is a 110 kDa androgen-dependent transcription factor that is a member of the steroid/nuclear receptor gene superfamily. The AR signaling pathway plays a key role in development and function of male reproductive organs, including the prostate and epididymis. AR also plays a role in nonreproductive organs, such as muscle, hair follicles, and brain. Abnormalities in the AR signaling pathway have been linked to a number of diseases, including prostate cancer, Kennedy's disease and male infertility. The PI3K/Akt signaling pathway plays an important role in regulating AR activity through phosphorylation of AR at Ser213/210 and Ser791/790. Growth factors or cytokines may induce phosphorylation of AR through the PI3K/Akt pathway. Activation of the PI3K/AKt pathway is thought to have a survival role in prostate cancer by protecting cells from apoptosis.

Long Name

Androgen Receptor

Alternate Names

AIS, AndrogenR, AR, DHTR, NR3C4, SBMA, SMAX1

Gene Symbol

AR

Additional Androgen R/NR3C4 Products

Product Documents for Androgen R/NR3C4 Antibody (CL9255)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Androgen R/NR3C4 Antibody (CL9255)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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