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Angiotensin I Antibody (BGN/KA/4H) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NB100-62344

Novus Biologicals, part of Bio-Techne
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NB100-62344

Key Product Details

Species Reactivity

Validated:

Human, Rat

Cited:

Human, Rat

Applications

Validated:

ELISA, Western Blot

Cited:

Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG2A Clone # BGN/KA/4H

Format

BSA Free

Concentration

1.0 mg/ml

Product Specifications

Immunogen

Synthetic peptide corresponding to amino acids 40-49 of the angiotensinogen precursor (Swiss-Prot entry P01019) conjugated to HMW carrier protein.

Epitope

P-F-H-L-V-I-H-N-E-S(-C)

Reactivity Notes

Use in Rat reported in scientific literature (PMID:33028854).

Specificity

NB100-62344 is specific for Angiotensin I and does not react with angiotensin II, III or angiotensinogen in ELISA. Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure. Angiotensin I is important in the Renin-Angiotensin-Aldosterone System (RAAS). RAAS is responsible for the regulation of blood pressure and water retention in the body. Angiotensin I is produced from a reaction between the renal enzyme Renin and angiotensinogen. It is converted by Angiotensin Converting Enzyme (ACE) into a vasoactive form called Angiotensin II which is responsible for increasing blood pressure.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG2A

Applications for Angiotensin I Antibody (BGN/KA/4H) - BSA Free

Application
Recommended Usage

ELISA

1:12000-1:100000
Application Notes
Use in Western Blot reported in scientific literature (PMID:33028854).

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.09% Sodium Azide

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Angiotensin I

The protein encoded by this gene, pre-angiotensinogen or angiotensinogen precursor, is expressed in the liver and is cleaved by the enzyme renin in response to lowered blood pressure. The resulting product, angiotensin I is then cleaved by angiotensin converting enzyme (ACE) to generate the physiologically active enzyme angiotensin II. The protein is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia.

Alternate Names

alpha-1 antiproteinase, antitrypsin, angiotensin II, angiotensinogen, angiotensinogen (serpin peptidase inhibitor, clade A, member 8), ANHU, FLJ92595, FLJ97926, pre-angiotensinogen, serine (or cysteine) proteinase inhibitor, Serpin A8, SERPINA8angiotensin I

Entrez Gene IDs

183 (Human)

Gene Symbol

AGT

UniProt

Additional Angiotensin I Products

Product Documents for Angiotensin I Antibody (BGN/KA/4H) - BSA Free

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Angiotensin I Antibody (BGN/KA/4H) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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