APBA3/Mint-3 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB120-3450

Novus Biologicals, part of Bio-Techne
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NB120-3450
NB120-3450-0.025mg
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Key Product Details

Species Reactivity

Mouse, Rat

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1 mg/ml

View all APBA3 Antibodies »

Product Specifications

Immunogen

Synthetic peptide corresponding to residues M(1) E F L P E P Q H P P G P P T M D L E(19) of rat Mint3.

Specificity

NB120-3450 detects munc-18 interacting protein 3 (Mint3) from mouse cells and rat brain samples.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for APBA3/Mint-3 Antibody

Western Blot: APBA3/Mint-3 Antibody [NB120-3450]

Western Blot: APBA3/Mint-3 Antibody [NB120-3450]

Western Blot: APBA3/Mint-3 Antibody [NB120-3450] - Analysis of Mint3 from AtT20 cell extract.

Applications for APBA3/Mint-3 Antibody

Application
Recommended Usage

Western Blot

2 ug/ml
Application Notes
WB: Detects an approx. 86 kDa protein representing Mint 3 from AtT20 cell extract.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS with 1 mg/ml BSA

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: APBA3

The munc-18 interacting (Mint) protein family is a group of evolutionarily conserved adaptor proteins that function in membrane transport and organization. In mammals, there exist three mint isoforms, Mint 1, 2, and 3. Although there is little amino acid sequence conservation in the amino-terminal half, the carboxy-terminal half of these proteins is highly conserved. Within this conserved portion there exists a phosphotyrosine-binding (PTB) and a PSD-95/DLG-A/ZO-1 (PDZ) domain, which function as protein interaction modules. Mint 1 and 2 appear to be expressed exclusively in the brain and are found to bind to munc-18, an essential component of the synaptic vesicle fusion machinery. Mint 3 is ubiquitously expressed in all tissues and is expressed at the lowest levels in the brain and testis. Studies show that Mint 3 does not interact with munc-18. Mint 3 has been found to interact with the Alzheimer's Disease-related amyloid precursor protein (APP) and does so through its PTB and PDZ domains. It has been suggested that Mint 3 links APP to other transport machinery components, thereby regulating it transport, endocytosis, and metabolism. Abnormal APP metabolism has been shown to be the cause of an early-onset type of Alzheimer's disease.

Long Name

Amyloid Beta [A4] Precursor Protein-binding, Family A, Member 3

Alternate Names

MINT3, X11L2

Entrez Gene IDs

83611 (Rat)

Gene Symbol

APBA3

Additional APBA3 Products

Product Documents for APBA3/Mint-3 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for APBA3/Mint-3 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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