Apc2 Antibody (3A2G2) - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-61656

Novus Biologicals, part of Bio-Techne
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NBP2-61656
NBP2-61656-0.025ml
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Key Product Details

Species Reactivity

Human

Applications

ELISA, Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 Clone # 3A2G2

Format

BSA Free

Concentration

1 mg/ml

View all Apc2 Antibodies »

Product Specifications

Immunogen

Purified recombinant fragment of human APC2 (AA: 2041-2181) expressed in E. Coli.

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1

Theoretical MW

244 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Apc2 Antibody (3A2G2) - BSA Free

Western Blot: Apc2 Antibody (3A2G2)BSA Free [NBP2-61656]

Western Blot: Apc2 Antibody (3A2G2)BSA Free [NBP2-61656]

Western Blot: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis using APC2 mAb against human APC2 (AA: 2041-2181) recombinant protein. (Expected MW is 40.9 kDa)
Immunocytochemistry/ Immunofluorescence: Apc2 Antibody (3A2G2) - BSA Free [NBP2-61656]

Immunocytochemistry/ Immunofluorescence: Apc2 Antibody (3A2G2) - BSA Free [NBP2-61656]

Immunocytochemistry/Immunofluorescence: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis of Hela cells using APC2 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Goat anti-Mouse IgG (H+L) DyLight 488 secondary antibody was used.
Immunohistochemistry: Apc2 Antibody (3A2G2) - BSA Free [NBP2-61656]

Immunohistochemistry: Apc2 Antibody (3A2G2) - BSA Free [NBP2-61656]

Immunohistochemistry: Apc2 Antibody (3A2G2) [NBP2-61656] - Analysis of paraffin-embedded bladder cancer tissues using APC2 mouse mAb with DAB staining.
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Applications for Apc2 Antibody (3A2G2) - BSA Free

Application
Recommended Usage

ELISA

1:10000

Flow Cytometry

1:200-1:400

Immunocytochemistry/ Immunofluorescence

1:200-1:1000

Immunohistochemistry

1:200-1:1000

Immunohistochemistry-Paraffin

1:200-1:1000

Western Blot

1:500-1:2000

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Format

BSA Free

Preservative

0.05% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Apc2

This gene encodes a strongly conserved protein that has an N-terminal coiled-coil domain followed by an armadillo domain, five 20-amino acid repeats, and two SAMP domains. This protein promotes the assembly of a multiprotein complex that recruits and phosphorylates the Wnt effector beta-catenin and targets beta-catenin for ubiquitylation and proteasomal degradation. This protein therefore plays a role in the reduction of cytoplasmic levels of beta-catenin which in turn reduces activation of Wnt target genes that play a pivotal role in the pathogenesis of various human cancers. The protein encoded by this gene is closely related to the adenomatous polyposis coli (APC) tumor-suppressor protein and has similar tumor-suppressor effects. This gene also plays a role in actin assembly, cell-cell adhesion, and microtubule network formation through its interaction with cytoskeletal proteins. This gene has its highest expression in the central nervous system and is involved in brain development through cytoskeletal regulation in neurons. Alternative splicing produces multiple transcript variants encoding distinct isoforms.

Alternate Names

adenomatosis polyposis coli 2, adenomatous polyposis coli like, adenomatous polyposis coli protein 2, APCL

Gene Symbol

APC2

Additional Apc2 Products

Product Documents for Apc2 Antibody (3A2G2) - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Apc2 Antibody (3A2G2) - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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