APE Antibody
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76495
Key Product Details
Species Reactivity
Validated:
Human
Predicted:
Mouse (94%), Rat (93%). Backed by our 100% Guarantee.
Applications
Immunocytochemistry/ Immunofluorescence
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Product Summary for APE Antibody
Immunogen
This antibody was developed against Recombinant Protein corresponding to amino acids: DKEGYSGVGLLSRQCPLKVSYGIGEEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAFRKFLKGLASRKPLVLCGDLNVAHEEIDLRNPKGNKKNAGFTPQEGAPHR
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for APE Antibody
![Immunocytochemistry/ Immunofluorescence: APE Antibody [NBP2-76495]](https://resources.bio-techne.com/images/products/APE-Antibody-Immunocytochemistry-Immunofluorescence-NBP2-76495-img0001.jpg "Immunocytochemistry/ Immunofluorescence: APE Antibody [NBP2-76495]")
Immunocytochemistry/ Immunofluorescence: APE Antibody [NBP2-76495]
Immunocytochemistry/Immunofluorescence: APE Antibody [NBP2-76495] - Staining of human cell line U-2 OS shows localization to nucleus. Antibody staining is shown in green.Applications for APE Antibody
Application
Recommended Usage
Immunocytochemistry/ Immunofluorescence
0.25-2 ug/ml
Application Notes
Immunocytochemistry/Immunofluorescence Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Affinity purified
Formulation
PBS, pH 7.2, containing 40% glycerol
Preservative
0.02% Sodium Azide
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: APE
For DNA repair, APE1 functions as a mammalian apurinic/apyrimidinic (AP) endodeoxyribonuclease responsible for the repair of AP sites in DNA lesions induced by oxidative and alkylating agents.
APEX1 also exerts a reversible nuclear redox activity to regulate the DNA binding affinity and the activity of transcriptional factors by regulating the redox status of their DNA-binding domains.
APE1 antibodies are useful for studies on both DNA repair and transcriptional regulation.
Long Name
Apurinic/Apyrimidinic Endonuclease
Alternate Names
APEX1
Gene Symbol
APEX1
Additional APE Products
Product Documents for APE Antibody
Product Specific Notices for APE Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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