Argininosuccinate Lyase Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-87462

Novus Biologicals, part of Bio-Techne
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NBP1-87462
NBP1-87462-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human, Canine

Cited:

Mouse, Canine

Predicted:

Mouse (92%). Backed by our 100% Guarantee.

Applications

Validated:

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Cited:

IF/IHC, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Argininosuccinate Lyase Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: MASESGKLWGGRFVGAVDPIMEKFNASIAYDRHLWEVDVQGSKAYSRGLEKAGLLTKAEMDQILHGLDKVAEEWAQGTFKLNSNDED

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (86%). Canine reactivity reported in scientific literature (PMID: 24945279).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Argininosuccinate Lyase Antibody

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462]

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462]

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462] - Staining in human liver and skeletal muscle tissues using NBP1-87462 antibody. Corresponding ASL RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462]

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462]

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462] - Staining of human kidney shows moderate to strong cytoplasmic positivity in cells in tubules.
Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462]

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462]

Immunohistochemistry-Paraffin: Argininosuccinate Lyase Antibody [NBP1-87462] - Staining of human liver shows strong cytoplasmic positivity in hepatocytes.
View 2 more images

Applications for Argininosuccinate Lyase Antibody

Application
Recommended Usage

Immunohistochemistry

1:1000 - 1:2500

Immunohistochemistry-Paraffin

1:1000-1:2500

Western Blot

Reported in (PMID:36256480)
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Argininosuccinate Lyase

Argininosuccinate Lyase encodes a member of the lyase 1 family. The encoded protein forms a cytosolic homotetramer and primarily catalyzes the reversible hydrolytic cleavage of argininosuccinate into arginine and fumarate, an essential step in the liver in detoxifying ammonia via the urea cycle. Mutations in this gene result in the autosomal recessive disorder argininosuccinic aciduria, or argininosuccinic acid lyase deficiency. A nontranscribed pseudogene is also located on the long arm of chromosome 22. Alternatively spliced transcript variants encoding different isoforms have been described.

Alternate Names

argininosuccinase, argininosuccinate lyase, Arginosuccinase, ASAL, EC 4.3.2.1

Gene Symbol

ASL

Additional Argininosuccinate Lyase Products

Product Documents for Argininosuccinate Lyase Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Argininosuccinate Lyase Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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