ARHGAP22 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-39028

Novus Biologicals, part of Bio-Techne
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NBP2-39028
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all ARHGAP22 Antibodies »

Product Summary for ARHGAP22 Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: DNVPAPGLVPGIPSVASMAWSGASSSESSVGGSLSSCTACRASDSSARSSLHTDWALEPSPLPSSSED

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ARHGAP22 Antibody

Western Blot: ARHGAP22 Antibody [NBP2-39028]

Western Blot: ARHGAP22 Antibody [NBP2-39028]

Western Blot: ARHGAP22 Antibody [NBP2-39028] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Human cell line RT-4
Immunohistochemistry: ARHGAP22 Antibody [NBP2-39028]

Immunohistochemistry: ARHGAP22 Antibody [NBP2-39028]

Immunohistochemistry: ARHGAP22 Antibody [NBP2-39028] - Staining of human testis shows strong nuclear positivity in Leydig cells.

Applications for ARHGAP22 Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ARHGAP22

ARHGAP22 is a Rho GTPase-activating protein involved in the signal transduction pathway that regulates endothelial cell capillary tube formation during angiogenesis. It acts as a GTPase activator for RAC1 by converting it to an inactive GDP-bound state and also inhibits RAC1-dependent lamellipodia formation. It may also play a role in transcription regulation via its interaction with VEZF1, by regulating activity of the endothelin-1 (EDN1) promoter.

Alternate Names

Rho GTPase activating protein 22, rho GTPase-activating protein 22, RHOGAP2, Rho-type GTPase-activating protein 22

Gene Symbol

ARHGAP22

UniProt

Q7Z5H3 (Human)

Additional ARHGAP22 Products

Product Documents for ARHGAP22 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ARHGAP22 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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