Ataxin-2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-76807

Novus Biologicals, part of Bio-Techne
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NBP2-76807
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Bovine (100%), Canine (100%), Mouse (100%), Porcine (100%). Backed by our 100% Guarantee.

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Peptide ELISA

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Ataxin-2 Antibodies »

Product Summary for Ataxin-2 Antibody

Immunogen

Peptide with sequence C-SEREGHSINTR, from the internal region of the protein sequence according to NP_002964.3; NP_001297050.1; NP_001297052.1.

Epitope

C-SEREGHSINTR

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Ataxin-2 Antibody

Immunocytochemistry/ Immunofluorescence: Ataxin-2 Antibody [NBP2-76807]

Immunocytochemistry/ Immunofluorescence: Ataxin-2 Antibody [NBP2-76807]

Immunocytochemistry/Immunofluorescence: Ataxin-2 Antibody [NBP2-76807] - Analysis of paraformaldehyde fixed A431 cells, permeabilized with 0.15% Triton. Primary incubation 1hr (1:50 dilution) followed by Alexa Fluor 488 secondary antibody (2 ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/ml) followed by Alexa Fluor 488 secondary antibody (2 ug/ml).
Flow Cytometry: Ataxin-2 Antibody [NBP2-76807]

Flow Cytometry: Ataxin-2 Antibody [NBP2-76807]

Flow Cytometry: Ataxin-2 Antibody [NBP2-76807] - Analysis of paraformaldehyde fixed A431 cells (blue line), permeabilized with 0.5% Triton. Primary incubation 1hr (1:50 dilution) followed by Alexa Fluor 488 secondary antibody (1 ug/ml). IgG control: Unimmunized goat IgG (black line) followed by Alexa Fluor 488 secondary antibody.
Immunocytochemistry/ Immunofluorescence: Ataxin-2 Antibody [NBP2-76807]

Immunocytochemistry/ Immunofluorescence: Ataxin-2 Antibody [NBP2-76807]

Immunocytochemistry/Immunofluorescence: Ataxin-2 Antibody [NBP2-76807] - Analysis of paraformaldehyde fixed U2OS cells, permeabilized with 0.15% Triton. Primary incubation 1hr (1:50 dilution) followed by Alexa Fluor 488 secondary antibody (2 ug/ml), showing cytoplasmic staining. The nuclear stain is DAPI (blue). Negative control: Unimmunized goat IgG (10 ug/ml) followed by Alexa Fluor 488 secondary antibody (2 ug/ml).

Applications for Ataxin-2 Antibody

Application
Recommended Usage

Flow Cytometry

10 ug/ml

Immunocytochemistry/ Immunofluorescence

10 ug/ml

Peptide ELISA

1:200
Application Notes
WB: Preliminary experiments in human brain (cerebellum and cerebral cortex) lysates gave no specific signal but low background.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Ataxin-2

The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. Defects in this gene are the cause of spinocerebellar ataxia type 2 (SCA2). SCA2 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA2 is caused by expansion of a CAG repeat in the coding region of this gene. Longer expansions result in earlier onset of the disease. Alternatively spliced transcript variants encoding different isoforms have been identified but their full length sequence has not been determined.

Alternate Names

ataxin 2, ataxin 2), ataxin-2, ATX2spinocerebellar ataxia 2 (olivopontocerebellar ataxia 2, autosomal dominant, SCA2FLJ46772, Spinocerebellar ataxia type 2 protein, TNRC13, trinucleotide repeat containing 13, Trinucleotide repeat-containing gene 13 protein

Entrez Gene IDs

6311 (Human); 20239 (Mouse)

Gene Symbol

ATXN2

UniProt

NP_002964.3 (Human), NP_001297050.1 (Human), NP_001297052.1 (Human)

Additional Ataxin-2 Products

Product Documents for Ataxin-2 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Ataxin-2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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