Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all ATP2C2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 19 amino acid synthetic peptide near the amino terminus of human ATP2C2. The immunogen is located within the first 50 amino acids of ATP2C2. Amino Acid Squence: RQYQALEKDEEEALIDEQS

Specificity

At least three isoforms of ATP2C2 are known to exist. ATP2C2 antibody will not cross-react with ATP2C1

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for ATP2C2 Antibody - BSA Free

ATP2C2 Antibody - BSA Free

Western Blot: ATP2C2 Antibody - BSA Free [NBP1-76567] -

Western Blot: ATP2C2 Antibody - BSA Free [NBP1-76567] - Western blot analysis of ATP2C2 in 3T3 cell lysate with ATP2C2 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
ATP2C2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: ATP2C2 Antibody - BSA Free [NBP1-76567] -

Immunocytochemistry/ Immunofluorescence: ATP2C2 Antibody - BSA Free [NBP1-76567] - Immunofluorescence of ATP2C2 in 3T3 cells with ATP2C2 antibody at 20 ug/mL.

Applications for ATP2C2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Western Blot

1 ug/ml

Reviewed Applications

Read 2 reviews rated 3 using NBP1-76567 in the following applications:

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: ATP2C2

ATP2C2, also known as secretory pathway Ca2+/Mn2+-ATPase (SPCA) 2, belongs to the family of P-type cation transport ATPases. This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium from the cytosol to the Golgi lumen. Defects in the related gene ATP2C1 cause Hailey-Hailey disease, for which ATP2C2 does not compensate, suggesting that ATP2C2 plays other physiological roles. Unlike ATP2C1, ATP2C2 has a much more restricted expression pattern and displays a higher maximal turnover rate for overall Ca2+-ATPase reaction and a lower apparent affinity for cytosolic Ca2+ activation of phosphorylation. Overexpression of ATP2C2 in mammary tumors result a Ca2+ influx via the store-operated Ca2+ channel ORAI1 and independent of the STIM1 and STIM2 sensors.

Alternate Names

ATPase 2C2, ATPase, Ca++ transporting, type 2C, member 2, calcium-transporting ATPase type 2C member 2, DKFZp686H22230, KIAA0703, secretory pathway Ca(2+)-ATPase 2, secretory pathway calcium ATPase 2, SPCA2

Gene Symbol

ATP2C2

UniProt

NP_055676 (Human)

Additional ATP2C2 Products

Product Documents for ATP2C2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for ATP2C2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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