Aurora C Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-90819

Novus Biologicals, part of Bio-Techne
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NBP1-90819
NBP1-90819-25ul
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Key Product Details

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Aurora C Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: AVVQLGKAQPAGEELATANQTAQQPSSPAMRRLTVDDF

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Aurora C Antibody

Immunohistochemistry: Aurora C Antibody [NBP1-90819]

Immunohistochemistry: Aurora C Antibody [NBP1-90819]

Immunohistochemistry: Aurora C Antibody [NBP1-90819] - Staining of human liver shows strong granular cytoplasmic positivity in hepatocytes.

Applications for Aurora C Antibody

Application
Recommended Usage

Immunohistochemistry

1:50 - 1:200

Immunohistochemistry-Paraffin

1:50 - 1:200
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Aurora C

Aurora-C is a member of a novel family of serine/threonine kinases that have been identified as key regulators of the mitotic cell division process (1). Studies show that human Aurora-C is a chromosomal passenger protein that forms complexes with Aurora-B and inner centromere protein (INCENP), which are known passenger proteins. INCENP binds and activates Aurora-C in vivo and in vitro. Aurora-C co-expressed with INCENP elicits the phosphorylation of endogenous histone H3 in mammalian cells, even though this phosphorylation is not sufficient to establish chromosome condensation in interphase cells (2). Over-expression of an inactive mutant of Aurora C impaired the localization of Aurora C to the spindle midzone resulting in multinucleation which demonstrates that Aurora C is required for cytokinesis (3).

Long Name

Aurora kinase C

Alternate Names

AIE2, AIK3, AIRK3, ARK-3, ARK3, AURKC, Aurora 3, EC 2.7.11.1, STK13

Gene Symbol

AURKC

Additional Aurora C Products

Product Documents for Aurora C Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Aurora C Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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