Bcl-10 Antibody (BL10/2988R) [Janelia Fluor® 646]
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-08803JF646
Recombinant Monoclonal Antibody
Conjugate
Catalog #
Forumulation
Catalog #
Key Product Details
Species Reactivity
Validated:
Human
Applications
Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Janelia Fluor 646
Antibody Source
Recombinant Monoclonal Rabbit IgG Clone # BL10/2988R
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Product Summary for Bcl-10 Antibody (BL10/2988R) [Janelia Fluor® 646]
Immunogen
Recombinant human Bcl-10 protein fragment (around aa122-168) (exact sequence is proprietary) (Uniprot: O95999)
Localization
Nucleus, Cytoplasm
Specificity
BCL10, with an N-terminal caspase recruitment domain (CARD), is found in a number of apoptotic regulatory molecules. It was identified through its direct involvement in t(1;14) of mucosa-associated lymphoid tissue (MALT) lymphoma. Expression of BCL10 was shown to induce NF B activation in a NIK-dependent pathway. This monoclonal antibody labels subpopulations of normal B and T cells and is a useful tool for the sub-classification of lymphomas. In MALT lymphomas with the t(1;14) translocation, while 55% of MALT lymphomas lacking this translocation exhibited the same labeling pattern, although at a much lower level.
Marker
MALT-Lymphoma Marker
Clonality
Monoclonal
Host
Rabbit
Isotype
IgG
Applications for Bcl-10 Antibody (BL10/2988R) [Janelia Fluor® 646]
Application
Recommended Usage
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Immunocytochemistry/ Immunofluorescence
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry
Optimal dilutions of this antibody should be experimentally determined.
Immunohistochemistry-Paraffin
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
Optimal dilution of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein A or G purified
Formulation
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Concentration
Please see the vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C in the dark.
Background: Bcl-10
Long Name
B Cell Lymphoma/Leukemia 10
Alternate Names
Bcl10, c-E10, CARMEN, CIPER, CLAP, mE10
Gene Symbol
BCL10
Additional Bcl-10 Products
Product Documents for Bcl-10 Antibody (BL10/2988R) [Janelia Fluor® 646]
Product Specific Notices for Bcl-10 Antibody (BL10/2988R) [Janelia Fluor® 646]
Sold under license from the Howard Hughes Medical Institute, Janelia Research Campus.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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