Bcl-2 related protein A1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-56070

Novus Biologicals, part of Bio-Techne
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NB100-56070
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat, Gerbil

Applications

Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

View all Bcl-2 related protein A1 Antibodies »

Product Summary for Bcl-2 related protein A1 Antibody

Immunogen

A synthetic peptide corresponding to amino acids 34-51 (CRVLQRVAFSVQKEVEKN) of mouse A1 was used as immunogen; GenBank no. AAH28762.1 Mouse A1 is a 172 amino acid protein.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Bcl-2 related protein A1 Antibody

Application
Recommended Usage

Immunoprecipitation

1:50-1:200

Western Blot

1:1000-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Unpurified

Formulation

Whole antisera

Preservative

0.05% Sodium Azide

Concentration

This product is unpurified. The exact concentration of antibody is not quantifiable.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Bcl-2 related protein A1

The Bcl-2 family of apoptosis-related genes plays central roles in regulating apoptotic pathways (reviewed in Thomadaki and Scorilas, 2006). Regulation of cell death through apoptosis is critical for the maintenance of homeostasis, defense against infectious agents, and normal development. Bcl-2 family proteins regulate apoptosis primarily through the regulation of mitochondrial outer membrane permeability. In mammals, the family consists of both antiapoptotic (prosurvival) and proapoptotic (prodeath) members. Cellular homeostasis is thought to be dependent on a balance between the actions of antiapoptotic and proapoptotic proteins. Bcl-2 family proteins can be divided into 3 main subfamilies on the basis of their function and the content of their Bcl-2 homology (BH) domains, for example: 1) Antiapoptotic : Bcl-2, Bcl-xL, Bcl-W, A1, and Mcl-1 2) Proapoptotic (multidomain): Bax, Bak, and Bok. 3) BH3-only (proapoptotic): Bad, Bcl-xS, Bid, Bik, Bim, Blk, Bmf, Bnip, Noxa, and Puma. Antiapoptotic members inhibit cells from undergoing apoptosis, whereas proapoptotic and BH3-only subfamily members promote apoptosis. There are 4 BH domains (1-4) conserved among Bcl-2 family proteins. The BH domains are important for function as well as for heterodimerization between family members. Typical antiapoptotic family members have all four BH domains (1-4), whereas proapoptotic (multidomain) members have BH1, 2 and 3 domains and BH3-only members have only the BH3 domain. Overall, the relative ratio of antiapoptotic and proapoptotic proteins determines the suseptibility of a cell to various apoptotic stimuli. Many Bcl-2 family proteins are differentially expressed in various malignancies and some are useful prognostic biomarkers. Antiapoptotic proteins are often elevated in diverse cancers and have the potential to confer resistance to both endogenous cell death stimuli and cancer treatments. Alterations in the ratio or levels of Bcl-2 family proteins have been also associated with nonmalignant diseases including neurodegenerative diseases, autoimmune diseases, AIDs, Down's syndrome, cardiovascular diseases, diabetes, glomerulonephritis, and muscular dystrophy. Recognizes A1 isoforms containing the peptide immungen sequence including A1-a, A1-b, and A1-d. Mouse A1-a is a 172 amino acid protein; GenBank no. AAH28762.1. Mouse A1-b has been described as both a 140 amino acid protein (GenBank no. AAG02475.1) and a 172 amino acid protein (GenBank no. NP_031560.1). Mouse A1-d is a 172 amino acid protein; GenBank no. NP_031562.1.

Alternate Names

BCL2A1, Bcl2L5, Bfl-1, GRS

Entrez Gene IDs

24224 (Rat)

Gene Symbol

BCL2

Additional Bcl-2 related protein A1 Products

Product Documents for Bcl-2 related protein A1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Bcl-2 related protein A1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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