BCR Antibody (S02-6I0)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-15006

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-15006-100ul
NBP3-15006-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S02-6I0

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all BCR Antibodies »

Product Summary for BCR Antibody (S02-6I0)

Immunogen

A synthetic peptide of human BCR (Uniprot#: P11274)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

160 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for BCR Antibody (S02-6I0)

Western Blot: BCR Antibody (S02-6I0) [NBP3-15006]

Western Blot: BCR Antibody (S02-6I0) [NBP3-15006]

Western Blot: BCR Antibody (S02-6I0) [NBP3-15006] - Western blot detection of BCR in A549, HL-60, U2OS, C6 cell lysates using BCR Rabbit mAb (1:1000 diluted). Predicted band size: 143kDa. Observed band size: 160kDa.
Immunohistochemistry-Paraffin: BCR Antibody (S02-6I0) [NBP3-15006]

Immunohistochemistry-Paraffin: BCR Antibody (S02-6I0) [NBP3-15006]

Immunohistochemistry-Paraffin: BCR Antibody (S02-6I0) [NBP3-15006] - Immunohistochemistry of BCR in paraffin-embedded Human Brain using BCR Rabbit mAb at dilution 1/50

Applications for BCR Antibody (S02-6I0)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine (pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BCR

The breakpoint cluster region protein (Bcr) is best know to be involved in genomic translocation with fusion partner Abl (Cbr-Abl) causing chronic myelogenous leukemia (CML) (1-2). This 160 kDa protein contains a serine/threonine kinase domain, an SH2 binding domain, a GTP/GDP exchange domain and a C-term domain which functions as a GTPase activating protein for p21rac and CDC42 (3). Additionally, Bcr is involved in signal transduction and can down regulate Ras mediated cell signaling (4).

Long Name

Breakpoint Cluster Region

Alternate Names

ALL, PHL

Gene Symbol

BCR

Additional BCR Products

Product Documents for BCR Antibody (S02-6I0)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BCR Antibody (S02-6I0)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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