Bestrophin 1 Antibody
Novus Biologicals, part of Bio-Techne | Catalog # NBP2-56225
Key Product Details
Species Reactivity
Human
Applications
Immunohistochemistry, Immunohistochemistry-Paraffin
Label
Unconjugated
Antibody Source
Polyclonal Rabbit IgG
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Product Specifications
Immunogen
This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: SQVRRKTVEFNLTDMPEIPENHLKEPLEQSPTNIHTTLKDHMDPYWALENRSVLHLNQGHCIALCPTPASLALSLPFLHNFLGFHHCQSTLDLRPALAWGIYLATFTGILGKCSGPFLTSPWYHPEDFLGPGE
Clonality
Polyclonal
Host
Rabbit
Isotype
IgG
Scientific Data Images for Bestrophin 1 Antibody
![Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225]](https://resources.bio-techne.com/images/products/Bestrophin-1-Antibody-Immunohistochemistry-Paraffin-NBP2-56225-img0002.jpg "Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225]")
Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225]
Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] - Staining of human retina shows strong membranous positivity in retinal pigment epithelium.
Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -
Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -Staining of human skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -
Immunohistochemistry-Paraffin: Bestrophin 1 Antibody [NBP2-56225] -Staining of human pancreas shows no positivity in exocrine glandular cells as expected.Applications for Bestrophin 1 Antibody
Application
Recommended Usage
Immunohistochemistry
1:500 - 1:1000
Immunohistochemistry-Paraffin
1:500 - 1:1000
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended
Formulation, Preparation, and Storage
Purification
Affinity purified
Formulation
PBS (pH 7.2) and 40% Glycerol
Preservative
0.02% Sodium Azide
Concentration
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Background: Bestrophin 1
Bestrophin-1, also known as best macular dystrophy (BMD) or vitelliform macular dystrophy (VMD2), is an inherited autosomal form of macular degeneration, characterized by a depressed light peak in the electrooculogram (EOG). Bestrophin 1 is a 68 kDa basolateral plasma membrane protein encoded by the VMD2 gene. Bestrophin 1's function is still unknown, but data suggests that it is a chloride channel that plays a role in generating the altered EOG in Best disease patients. In addition, Bestrophin-1 is a useful biochemical and histological marker of RPE (retinal pigment epithelial cells) cells.
Bestrophin antibodies are useful tools for studies involving vision and retinal disease. .
Alternate Names
ARB, BEST, Best disease, bestrophin 1, bestrophin-1, BMD, TU15B, vitelliform macular dystrophy 2, Vitelliform macular dystrophy protein 2, VMD2RP50
Gene Symbol
BEST1
Additional Bestrophin 1 Products
Product Documents for Bestrophin 1 Antibody
Product Specific Notices for Bestrophin 1 Antibody
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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