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beta-2 Adrenergic R/ADRB2 Antibody (4C11)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-26521

Recombinant monoclonal antibody expressed in HEK293F cells
Novus Biologicals, part of Bio-Techne
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NBP3-26521-100ul
NBP3-26521-50ul

Key Product Details

Species Reactivity

Validated:

Human

Applications

ELISA, Immunohistochemistry

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # 4C11

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Product Summary for beta-2 Adrenergic R/ADRB2 Antibody (4C11)

Immunogen

A synthesized peptide derived from Human beta-2 Adrenergic R/ADRB2 [UniProt P07550]

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for beta-2 Adrenergic R/ADRB2 Antibody (4C11)

beta-2 Adrenergic R/ADRB2 Antibody (4C11)

Immunohistochemistry: beta-2 Adrenergic R/ADRB2 Antibody (4C11) [NBP3-26521] -

Immunohistochemistry: beta-2 Adrenergic R/ADRB2 Antibody (4C11) [NBP3-26521] - Image of beta-2 Adrenergic R/ADRB2 Antibody (4C11) diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.
beta-2 Adrenergic R/ADRB2 Antibody (4C11)

Immunohistochemistry: beta-2 Adrenergic R/ADRB2 Antibody (4C11) [NBP3-26521] -

Immunohistochemistry: beta-2 Adrenergic R/ADRB2 Antibody (4C11) [NBP3-26521] - Image of beta-2 Adrenergic R/ADRB2 Antibody (4C11) diluted at 1:100 and staining in paraffin-embedded human endometrial cancer performed. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4C overnight. The primary is detected by a Goat anti-rabbit IgG polymer labeled by HRP and visualized using 0.05% DAB.

Applications for beta-2 Adrenergic R/ADRB2 Antibody (4C11)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl and 50% glycerol

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20 to -70C. Avoid freeze-thaw cycles.

Background: beta-2 Adrenergic R/ADRB2

The beta-2 adrenoceptor (ADRB2) is an Adrenergic Receptor expressed in smooth muscle and metabolic tissues. Activation of this receptor induces a decrease in gastrointestinal motility, bronchodilation, vasodilation in skeletal and cardiac muscle, and glycogenolysis in liver. The beta-2 adrenoceptor is also a major lipolytic receptor in human fat cells and may be involved in obesity. Agonists of ADRB2 are most widely used for the treatment of asthma. In complex with beta-arrestin-1 and c-src, the beta-2 adrenergic receptor activates MAP kinases ERK1(MAPK3) and ERK2 (MAPK1). Expression of the beta-2 adrenoceptor has been reported in adipose, blood, brain, heart, lung, nose, pancreas, skeletal muscle, skin, and vessel. ESTs have been isolated from breast, liver, liver/spleen, placenta, and uterus libraries.

Long Name

Beta-2 Adrenergic Receptor

Alternate Names

ADRB2, ADRB2R, B2AR, beta-2 AdrenergicR, beta2 AdrenergicR

Gene Symbol

ADRB2

Additional beta-2 Adrenergic R/ADRB2 Products

Product Documents for beta-2 Adrenergic R/ADRB2 Antibody (4C11)

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for beta-2 Adrenergic R/ADRB2 Antibody (4C11)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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