beta-2 Adrenergic R/ADRB2 Antibody (6H8)
Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11204
Key Product Details
Species Reactivity
Validated:
Human, Rat, Guinea Pig
Applications
Flow Cytometry, Functional, Immunoassay
Label
Unconjugated
Antibody Source
Monoclonal Mouse IgG1 Clone # 6H8
Concentration
0.1 mg/ml
Product Summary for beta-2 Adrenergic R/ADRB2 Antibody (6H8)
Immunogen
Free peptide Beta2-H19C
Clonality
Monoclonal
Host
Mouse
Isotype
IgG1
Applications for beta-2 Adrenergic R/ADRB2 Antibody (6H8)
Application
Recommended Usage
Flow Cytometry
Optimal dilutions of this antibody should be experimentally determined.
Functional
Optimal dilutions of this antibody should be experimentally determined.
Immunoassay
Optimal dilutions of this antibody should be experimentally determined.
Application Notes
For Flow Cytometry, dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For functional studies, in vitro dilutions have to be optimized in user's experimental setting.
Please Note: Optimal dilutions of this antibody should be experimentally determined.
Formulation, Preparation, and Storage
Purification
Protein G purified
Endotoxin Level
<24 EU/mg
Formulation
0.2 um filtered solution in PBS, 0.1% BSA
Preservative
No Preservative
Concentration
0.1 mg/ml
Shipping
The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.
Stability & Storage
Store at 4C.
Background: beta-2 Adrenergic R/ADRB2
B2-receptors are mainly postsynaptic and are located on a number of tissues including blood vessels, bronchi, GIT, skeletal muscle, liver and mast cell. Activation results in vasodilatation, bronchodilation, relaxation of the GIT, glycogenolysis in the liver, tremor in skeletal muscle and inhibition of histamine release from mast cells.
Transduction is via G-proteins coupled to the intracellular second messenger adenylate cyclase. B-receptors are positively coupled to adenylate cyclase via activation of Gs G-protein, however activation of the b2-adrenoceptors results in stimulation and inhibition of adenylate cyclase. The b2-receptor selective agonists are widely used in the treatment of asthma and other related bronchospastic conditions. They are commonly used in the treatment of angina pectoris, cardiac arrhythmia and for the long-term treatment of patients who survive myocardial infarction. B-receptor antagonists have also been used as anti-hypertensive for a number of years. Beta -blockers have also proven useful in the treatment of conditions such as migraine, anxiety disorders, hyperthyroidism, alcohol withdrawal and when applied topically are useful in the treatment of glaucoma and ocular hypertension.
Long Name
Beta-2 Adrenergic Receptor
Alternate Names
ADRB2, ADRB2R, B2AR, beta-2 AdrenergicR, beta2 AdrenergicR
Gene Symbol
ADRB2
Additional beta-2 Adrenergic R/ADRB2 Products
Product Documents for beta-2 Adrenergic R/ADRB2 Antibody (6H8)
Product Specific Notices for beta-2 Adrenergic R/ADRB2 Antibody (6H8)
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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