beta-3 Adrenergic R/ADRB3 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NLS4198

Novus Biologicals, part of Bio-Techne
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NLS4198
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Key Product Details

Species Reactivity

Validated:

Human, Rat

Cited:

Human, Rat

Predicted:

Primate (100%). Backed by our 100% Guarantee.

Applications

Validated:

Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin

Cited:

IF/IHC, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all beta-3 Adrenergic R/ADRB3 Antibodies »

Product Specifications

Immunogen

Synthetic 20 amino acid peptide from N-terminal extracellular domain of human beta-3 Adrenergic R/ADRB3.

Epitope

N-Terminus extracellular domain

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (95%), Rabbit (85%), Sheep (80%), Goat (80%), Hamster (80%), Feline (80%), Bovine (80%), Equine (80%).

Specificity

Human ADRB3. BLAST analysis of the peptide immunogen showed no homology with other human proteins.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Product can be stored undiluted at 4C for up to 1 month.

Scientific Data Images for beta-3 Adrenergic R/ADRB3 Antibody - BSA Free

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody - BSA Free [NLS4198]

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody - BSA Free [NLS4198]

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody [NLS4198] - Analysis of beta-3 Adrenergic R/ADRB3 Antibody with Adipose tissue.
Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody - BSA Free [NLS4198]

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody - BSA Free [NLS4198]

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody [NLS4198] - Analysis of anti-ADRB3 antibody with human adipose.
Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody - BSA Free [NLS4198]

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody - BSA Free [NLS4198]

Immunohistochemistry-Paraffin: beta-3 Adrenergic R/ADRB3 Antibody [NLS4198] - Human Brain, Glioblastoma tissue after heat-induced antigen retrieval.
View 4 more images

Applications for beta-3 Adrenergic R/ADRB3 Antibody - BSA Free

Application
Recommended Usage

Immunohistochemistry-Paraffin

10 - 15 ug/ml
Application Notes
Use in IHC reported in scientific literature (PMID: 29635716)..
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.1% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.

Background: beta-3 Adrenergic R/ADRB3

The Beta-3 Adrenoceptor (ADRB3) is an Adrenergic Receptor that stimulates lipolysis and increases fatty acids in the blood. Stimulation of the beta-3 adrenoceptor leads to lipolysis in white adipocytes and nonshivering thermogenesis in brown fat. The beta-3 adrenoceptor has also been suggested to affect the physiological control of cardiac and vascular contractility; beta-3 adrenoceptor stimulation decreases cardiac contractility through activation of a nitric oxide synthase pathway. A variant of the beta-3 adrenoceptor, Trp64Arg, has been shown to be associated with weight gain (obesity) and susceptibility to non-insulin-dependent diabetes mellitus (NIDDM), but not with coronary artery disease. Trp64Arg variant receptor has been shown to predict a greater tendency to develop abdominal adiposity and high blood pressure with advancing age. ADRB3 has been suggested to be responsible for the negative inotropic effects of catecholamines and may be involved in pathophysiological mechanisms leading to heart failure; ADRB3 is also one of the molecular targets under active research in the treatment of obeisity. Beta-3 adrenoceptor expression has been documented in adipose, heart, and in smooth muscle of digestive and urinary tract organs (bladder, colon, small intestine, stomach, ureter). Utilization of alternate promoters and/or 3-prime untranslated regions may result in tissue-specific regulation of the expression of ADRB3. ESTs have been isolated from heart/melanocyte/uterus and placenta libraries.

Long Name

Beta-3 Adrenergic Receptor

Alternate Names

ADRB3, ADRB3R, B3AR, beta-3 AdrenergicR, beta3 AdrenergicR

Entrez Gene IDs

155 (Human)

Gene Symbol

ADRB3

UniProt

P13945

Additional beta-3 Adrenergic R/ADRB3 Products

Product Documents for beta-3 Adrenergic R/ADRB3 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for beta-3 Adrenergic R/ADRB3 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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