Bradykinin Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-62405

Novus Biologicals, part of Bio-Techne
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NB100-62405-0.1ml
NB100-62405
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Key Product Details

Species Reactivity

Non-species specific

Applications

ELISA

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

5.0 mg/ml

View all Bradykinin Antibodies »

Product Specifications

Immunogen

Bradykinin peptide (RPPGFSPFR) conjugated to bovine serum albumin

Epitope

RPPGFSPFR

Specificity

NB100-62405 is specific for Bradykinin and Lys-Bradykinin (kallidin)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Bradykinin Antibody

Application
Recommended Usage

ELISA

1:50-1:500

Formulation, Preparation, and Storage

Purification

Protein G purified

Formulation

PBS

Preservative

0.09% Sodium Azide

Concentration

5.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Bradykinin

Bradykinin is a nine amino acid vasoactive peptide which elicits numerous physiologic responses such as vasodilation, smooth muscle spasm and pain. Bradykinin is one of a family of such peptides called the kinins. These kinins are generated by proteolysis of high molecular weight precursors called kininogens upon activation by pathophysiologic conditions such as inflammation or allergy. The physiological actions of these kinins are brought about through their interaction with transmembrane receptors. There are two distinct bradykinin receptor subtypes; B1 and B2, both of which appear to be coupled to G-proteins. The B2 receptor subtype is found in healthy smooth muscle cells and neurons, whereas the B1 receptors are only detected following tissue injury. The B2 receptor is similar in structure to other seven helix G protein coupled receptors. Bradykinin has relatively low affinity for B1 receptors, interacting primarily with the B2 receptor through which several second messenger systems are stimulated, including inositol phospholipid hydrolysis, arachidonic acid metabolism, tyrosine phosphorylation, and membrane depolarization and hyperpolarization.

Alternate Names

Alpha-2-thiol proteinase inhibitor, BDK, BK, bradykinin, Fitzgerald factor, High molecular weight kininogen, HMWK, kininogen-1, KNG1, Williams-Fitzgerald-Flaujeac factor

Entrez Gene IDs

3827 (Human); 16644 (Mouse); 24903 (Rat)

Gene Symbol

KNG1

Additional Bradykinin Products

Product Documents for Bradykinin Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Bradykinin Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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