Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Predicted:

Bovine (100%), Chicken (100%). Backed by our 100% Guarantee.

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all BRE Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 18 amino acid synthetic peptide from near the amino terminus of human BRCC45. The immunogen is located within the last 50 amino acids of BRCC45. Amino Acid Squence: YSQAQKNYPYSPRWDGNE

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BRE Antibody - BSA Free

Western Blot: BRE AntibodyBSA Free [NBP1-76830]

Western Blot: BRE AntibodyBSA Free [NBP1-76830]

Western Blot: BRE Antibody [NBP1-76830] - HeLa cell lysate in (A) the absence and (B) presence of blocking peptide with BRE antibody at 1 ug/ml.
Immunohistochemistry-Paraffin: BRE Antibody - BSA Free [NBP1-76830]

Immunohistochemistry-Paraffin: BRE Antibody - BSA Free [NBP1-76830]

Immunohistochemistry-Paraffin: BRE Antibody [NBP1-76830] - Human brain tissue with BRE antibody at 2.5 ug/ml.
BRE Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: BRE Antibody - BSA Free [NBP1-76830] -

Immunocytochemistry/ Immunofluorescence: BRE Antibody - BSA Free [NBP1-76830] - Immunofluorescence of BRE in human brain tissue with BRE antibody at 20 ug/mL.

Applications for BRE Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

1 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BRE

BRCC45 was initially suggested to be a housekeeping protein that is highly expressed in brain and reproductive organs. Later experiments indicated BRCC45 forms a complex with the breast and ovarian predisposition proteins BRCA1 and BRCA2 as well as RAD51 and BRCC36. This complex has a ubiquitin E3 ligase activity and is thought to enhance cellular survival following DNA damage. BRCC45 has also been suggested to function as a death receptor-associated anti-apoptotic protein by inhibiting the BID-induced activation of the mitochondrial apoptotic pathway. Higher levels of BRCC45 were detected in the majority of hepatocellular carcinomas, suggesting that BRCC45 may promote tumorigenesis when overexpressed. At least three isoforms of BRCC45 are known to exist.

Alternate Names

brain and reproductive organ-expressed (TNFRSF1A modulator), BRCA1/BRCA2-containing complex subunit 45, subunit 4

Gene Symbol

BABAM2

UniProt

NP_004890 (Human)

Additional BRE Products

Product Documents for BRE Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for BRE Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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