Key Product Details

Species Reactivity

Human, Mouse

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all BRSK2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 23 amino acid synthetic peptide from near the carboxy terminus of human BRSK2. The immunogen is located within amino acids 630 - 680 of BRSK2. Amino Acid Squence: DPPAAQHLSDTTNNCMEMMTGRLS

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Rat (87%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for BRSK2 Antibody - BSA Free

Western Blot: BRSK2 AntibodyBSA Free [NBP1-77281]

Western Blot: BRSK2 AntibodyBSA Free [NBP1-77281]

Western Blot: BRSK2 Antibody [NBP1-77281] - Analysis of BRSK2 in human brain tissue lysate with BRSK2 antibody at (A) 0.5, (B) 1 and (C) 2 ug/mL.
BRSK2 Antibody - BSA Free

Immunohistochemistry: BRSK2 Antibody - BSA Free [NBP1-77281] -

Immunohistochemistry: BRSK2 Antibody - BSA Free [NBP1-77281] - Immunohistochemistry of BRSK2 in human brain tissue with BRSK2 antibody at 5 u/mL.
BRSK2 Antibody - BSA Free

Immunocytochemistry/ Immunofluorescence: BRSK2 Antibody - BSA Free [NBP1-77281] -

Immunocytochemistry/ Immunofluorescence: BRSK2 Antibody - BSA Free [NBP1-77281] - Immunofluorescence of BRSK2 in Human Brain cells with BRSK2 antibody at 20 u/mL.
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Applications for BRSK2 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

0.5-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: BRSK2

BRSK2 was initially identified through a computer screen of the human genome and shows significant homology to the C. elegans neuronal cell polarity regulator SAD1. BRSK2 is expressed in the brain and to a lesser extent in the testes. BRSK2 is a member of the AMP-activated protein kinase subfamily and can be activated by the tumor suppressor kinase LKB1. More recently, it has been shown that both BRSK2 and the related protein BRSK1 are required for mammalian neuronal polarization. While BRSK1- and BRSK2-null mice were viable, double-mutant mice died within two hours of birth. Neurons from these mice showed uniformly-sized neurites as opposed to the normal long axon and multiple shorter dendrites. These neurites also displayed both axonal and dendritic markers. BRSK2 has also been shown to be an autoantigen in paraneoplastic limbic encephalitis. At least four isoforms of BRSK2 are known to exist.

Alternate Names

BR serine/threonine kinase 2, BR serine/threonine-protein kinase 2, C11orf7, chromsosome 11 open reading frame 7, EC 2.7.11, EC 2.7.11.1, FLJ41362, PEN11BSAD1, protein kinase SAD1B, serine/threonine kinase 29, serine/threonine kinase SAD-A, Serine/threonine-protein kinase 29, Serine/threonine-protein kinase SAD-A, STK29

Gene Symbol

BRSK2

UniProt

Q8IWQ3 (Human)

Additional BRSK2 Products

Product Documents for BRSK2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for BRSK2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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