C1q Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-11273

Novus Biologicals, part of Bio-Techne
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NBP3-11273
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Key Product Details

Species Reactivity

Validated:

Rat

Applications

Immunoassay, Immunohistochemistry-Frozen, Immunoprecipitation

Label

Unconjugated

Antibody Source

Polyclonal Rabbit

Concentration

0.1 mg/ml

View all C1q Antibodies »

Product Summary for C1q Antibody

Immunogen

The polyclonal antibody recognizes rat C1q.

Clonality

Polyclonal

Host

Rabbit

Applications for C1q Antibody

Application
Recommended Usage

Immunohistochemistry-Frozen

1:50
Application Notes
For Immunohistochemistry dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

0.2 um filtered solution in PBS, 0.1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: C1q

The polyclonal antibody recognizes rat C1q, a 459 kDa molecule consisting of three individual polypeptide chains. C1q composes together with C1r and C1s the C1 macromolecule, the first component of the classical complement pathway. Interaction of immune complexes with C1q induces a conformational change within the C1 complex, which results in activation of the classical pathway. C1q functions as recognition unit by binding to the heavy chain of IgG or IgM (Fc gamma and Fc micro) provided that the immunoglobulins are bound to their antigen. Furthermore C1q can bind to apoptotic blebs, where it activates the classical complement pathway and mediates phagocytosis. As such, C1q promotes the clearance of apoptotic cells and subsequent exposure of auto antigens, thereby preventing stimulation of the immune system. C1q is predominantly produced by macrophages but also by follicular dendritic cells, interdigitating cells and cells of the monocyte-macrophage lineage. C1q deficiency has a profound effect on host defence and clearance of immune complexes. Absence of C1q may cause autoimmunity by impairment of the clearance of apoptotic cells. Inherited C1q deficiency is also associated with the development of systemic lupus erythematosus (SLE).

Alternate Names

A chain, complement component 1, q subcomponent, A chain, complement component 1, q subcomponent, alpha polypeptide

Gene Symbol

C1QA

Additional C1q Products

Product Documents for C1q Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for C1q Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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