CAB39 Antibody (S03-4G7)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-19841

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # S03-4G7

Concentration

0.3 mg/ml

View all CAB39 Antibodies »

Product Summary for CAB39 Antibody (S03-4G7)

Immunogen

A synthetic peptide of human CAB39 (Uniprot # Q9Y376)

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

39 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for CAB39 Antibody (S03-4G7)

Western Blot: CAB39 Antibody (S03-4G7) [NBP3-19841]

Western Blot: CAB39 Antibody (S03-4G7) [NBP3-19841]

Western Blot: CAB39 Antibody (S03-4G7) [NBP3-19841] - Western blot detection of CAB395 in Hela, A549, HL-60, U2OS, U87-MG cell lysates using NBP3-19841 (1:1000 diluted). Predicted band size: 40kDa. Observed band size: 39kDa.
Immunohistochemistry-Paraffin: CAB39 Antibody (S03-4G7) [NBP3-19841]

Immunohistochemistry-Paraffin: CAB39 Antibody (S03-4G7) [NBP3-19841]

Immunohistochemistry-Paraffin: CAB39 Antibody (S03-4G7) [NBP3-19841] - Immunohistochemistry of CAB39 in paraffin-embedded Human Cholangiocarcinoma using NBP3-19841 at dilution 1/50

Applications for CAB39 Antibody (S03-4G7)

Application
Recommended Usage

Immunohistochemistry

1/20

Western Blot

1/1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

50mM Tris-Glycine(pH 7.4), 0.15M NaCl, 40% Glycerol, 0.05% BSA

Preservative

0.01% Sodium Azide

Concentration

0.3 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CAB39

Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity (1). Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms (2).

Alternate Names

calcium binding protein 39, calcium-binding protein 39, FLJ22682, MO25CGI-66, Protein Mo25

Gene Symbol

CAB39

Additional CAB39 Products

Product Documents for CAB39 Antibody (S03-4G7)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CAB39 Antibody (S03-4G7)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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