CAB39 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # H00051719-B01P

Novus Biologicals, part of Bio-Techne
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Key Product Details

Species Reactivity

Human

Applications

Proximity Ligation Assay, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Mouse IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all CAB39 Antibodies »

Product Specifications

Immunogen

CAB39 (NP_057373.1, 1 a.a. - 341 a.a.) full-length human protein. MPFPFGKSHKSPADIVKNLKESMAVLEKQDISDKKAEKATEEVSKNLVAMKEILYGTNEKEPQTEAVAQLAQELYNSGLLSTLVADLQLIDFEGKKDVAQIFNNILRRQIGTRTPTVEYICTQQNILFMLLKGYESPEIALNCGIMLRECIRHEPLAKIILWSEQFYDFFRYVEMSTFDIASDAFATFKDLLTRHKLLSAEFLEQHYDRFFSEYEKLLHSENYVTKRQSLKLLGELLLDRHNFTIMTKYISKPENLKLMMNLLRDKSRNIQFEAFHVFKVFVANPNKTQPILDILLKNQAKLIEFLSKFQNDRTEDEQFNDEKTYLVKQIRDLKRPAQQEA

Specificity

CAB39 - calcium binding protein 39,

Clonality

Polyclonal

Host

Mouse

Isotype

IgG

Scientific Data Images for CAB39 Antibody

Western Blot: CAB39 Antibody [H00051719-B01P]

Western Blot: CAB39 Antibody [H00051719-B01P]

Western Blot: CAB39 Antibody [H00051719-B01P] - Analysis of CAB39 expression in transfected 293T cell line by CAB39 polyclonal antibody. Lane 1: CAB39 transfected lysate(37.51 KDa). Lane 2: Non-transfected lysate.
Proximity Ligation Assay: CAB39 Antibody [H00051719-B01P]

Proximity Ligation Assay: CAB39 Antibody [H00051719-B01P]

Proximity Ligation Assay: CAB39 Antibody [H00051719-B01P] - Analysis of protein-protein interactions between STK11 and CAB39. HeLa cells were stained with anti-STK11 rabbit purified polyclonal 1:1200 and anti-CAB39 mouse purified polyclonal antibody 1:50. Each red dot represents the detection of protein-protein in

Applications for CAB39 Antibody

Application
Recommended Usage

Western Blot

1:500
Application Notes
Antibody reactive against Recombinant Protein with GST tag on ELISA and Western Blot and also on transfected lysate in western blot. GST tag alone is used as a negative control.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS (pH 7.4)

Preservative

No Preservative

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.

Background: CAB39

Mouse protein 25 alpha (MO25 alpha) is a 40-kDa protein that, together with the STE20-related adaptor-alpha (STRAD alpha) pseudo kinase, forms a regulatory complex capable of stimulating the activity of the LKB1 tumor suppressor protein kinase. The latter is mutated in the inherited Peutz-Jeghers cancer syndrome (PJS). MO25 alpha binds directly to a conserved Trp-Glu-Phe sequence at the STRAD alpha C terminus, markedly enhancing binding of STRAD alpha to LKB1 and increasing LKB1 catalytic activity (1). Skeletal muscle contraction results in the phosphorylation and activation of the AMP-activated protein kinase (AMPK) by an upstream kinase (AMPKK). The LKB1-STE-related adaptor (STRAD)-mouse protein 25 (MO25) complex is the major AMPKK in skeletal muscle; however, LKB1-STRAD-MO25 activity is not increased by muscle contraction. This relationship suggests that phosphorylation of AMPK by LKB1-STRAD-MO25 during skeletal muscle contraction may be regulated by allosteric mechanisms (2).

Alternate Names

calcium binding protein 39, calcium-binding protein 39, FLJ22682, MO25CGI-66, Protein Mo25

Entrez Gene IDs

51719 (Human)

Gene Symbol

CAB39

UniProt

NP_057373.1 (Human)

Additional CAB39 Products

Product Documents for CAB39 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for CAB39 Antibody

This product is produced by and distributed for Abnova, a company based in Taiwan.

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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