CACNB4 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-55414

Novus Biologicals, part of Bio-Techne
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NB100-55414
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Canine (100%), Mouse (100%), Rat (100%). Backed by our 100% Guarantee.

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all CACNB4 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-DYPDSYQDTYKPH corresponding to internal region (near C-Terminus) according to NP_000717.2, NP_001005746.1.

Epitope

DYPDSYQDTYKPH

Specificity

This antibody is expected to recognise all three reported isoforms (NP_001005747.1; NP_000717.2; NP_001005746.1).

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for CACNB4 Antibody

Western Blot: CACNB4 Antibody [NB100-55414]

Western Blot: CACNB4 Antibody [NB100-55414]

Western Blot: CACNB4 Antibody [NB100-55414] - (0.2ug/ml) staining of Human Bone Marrow lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for CACNB4 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:4000

Western Blot

0.2 - 0.6 ug/ml
Application Notes
WB: Approx. 55-60 kDa band observed in human bone marrow lysates (calculated MW of 54.7 kDa band according to NP_001005747.1 and 58.2 kDa band according to NP_000717.2).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: CACNB4

This gene encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Long Name

Voltage-dependent L-type calcium channel subunit beta-4

Alternate Names

CAB4, CACNLB4

Entrez Gene IDs

785 (Human); 12298 (Mouse); 58942 (Rat)

Gene Symbol

CACNB4

UniProt

NP_001005747.1 (Human)

Additional CACNB4 Products

Product Documents for CACNB4 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CACNB4 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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