CACNB4 encodes a member of the beta subunit family, a protein in the voltage-dependent calcium channel complex. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization and consist of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. Various versions of each of these subunits exist, either expressed from similar genes or the result of alternative splicing. The protein described in this record plays an important role in calcium channel function by modulating G protein inhibition, increasing peak calcium current, controlling the alpha-1 subunit membrane targeting and shifting the voltage dependence of activation and inactivation. Certain mutations in this gene have been associated with idiopathic generalized epilepsy (IGE) and juvenile myoclonic epilepsy (JME). Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized.

Long Name

Voltage-dependent L-type calcium channel subunit beta-4

Alternate Names

CAB4, CACNLB4

Gene Symbol

CACNB4

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Product Specific Notices for CACNB4 Antibody [FITC]

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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CACNB4 Antibody [FITC]

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-98196F

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Product Summary for CACNB4 Antibody [FITC]

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Immunohistochemistry-Paraffin

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Background: CACNB4