Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all CALHM1 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 17 amino acid synthetic peptide near the amino terminus of human CALHM1. The immunogen is located within amino acids 60 - 110 of CALHM1. Amino Acid Squence: AEEWKRPLGRRAKDPA

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CALHM1 Antibody - BSA Free

Western Blot: CALHM1 AntibodyBSA Free [NBP1-77112]

Western Blot: CALHM1 AntibodyBSA Free [NBP1-77112]

Western Blot: CALHM1 Antibody [NBP1-77112] - Rat liver tissue lysate at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry-Paraffin: CALHM1 Antibody - BSA Free [NBP1-77112]

Immunohistochemistry-Paraffin: CALHM1 Antibody - BSA Free [NBP1-77112]

Immunohistochemistry-Paraffin: CALHM1 Antibody [NBP1-77112] - Rat liver tissue with CALHM1 antibody at 5 ug/mL.

Immunocytochemistry/Immunofluorescence: CALHM1 Antibody [NBP1-77112] -

Immunocytochemistry/Immunofluorescence: CALHM1 Antibody [NBP1-77112] - Immunofluorescence of CALHM1 in Rat Liver cells with CALHM1 antibody at 20 ug/mL.
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Applications for CALHM1 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1-2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CALHM1

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by a massive loss of neurons in several brain regions and by the presence of senile plaques comprised of aggregated amyloid-beta (Abeta) peptides produced by the endoproteolysis of the amyloid precursor protein (APP). The calcium homeostasis modulator 1 (CALHM1) is a recently identified multipass transmembrane glycoprotein that controls cytosolic Ca2+ concentration and Abeta levels. While some studies suggest CALHM1 is significantly associated with risk of AD, other reports suggest there is no link. CALHM1 has been suggested to modulate the Ca2+-dependent proteolytic process of APP through controlling the level of cytosolic Ca2+.

Alternate Names

calcium homeostasis modulator 1, FAM26Ccalcium homeostasis modulator protein 1, family with sequence similarity 26, member C, MGC39514, MGC39617, Protein FAM26C

Gene Symbol

CALHM1

UniProt

NP_001001412 (Human)

Additional CALHM1 Products

Product Documents for CALHM1 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CALHM1 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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