Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Calpain 6 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 18 amino acid synthetic peptide from near the carboxy terminus of human CAPN6. The immunogen is located within the last 50 amino acids of CAPN6. Amino Acid Squence: KQGHISFKVISSDDLTEL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Calpain 6 Antibody - BSA Free

Western Blot: Calpain 6 AntibodyBSA Free [NBP1-76937]

Western Blot: Calpain 6 AntibodyBSA Free [NBP1-76937]

Western Blot: Calpain 6 Antibody [NBP1-76937] - Rat lung tissue lysate with Calpain 6 antibody at (A) 0.5 and (B) 1 ug/ml.
Immunocytochemistry/ Immunofluorescence: Calpain 6 Antibody - BSA Free [NBP1-76937]

Immunocytochemistry/ Immunofluorescence: Calpain 6 Antibody - BSA Free [NBP1-76937]

Immunocytochemistry/Immunofluorescence: Calpain 6 Antibody [NBP1-76937] - Calpain 6 in Human Lung cells with CAPN6 antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: Calpain 6 Antibody - BSA Free [NBP1-76937]

Immunohistochemistry-Paraffin: Calpain 6 Antibody - BSA Free [NBP1-76937]

Immunohistochemistry-Paraffin: Calpain 6 Antibody [NBP1-76937] - Human lung tissue with Calpain 6 antibody at 2.5 ug/ml.
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Applications for Calpain 6 Antibody - BSA Free

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

20 ug/ml

Immunohistochemistry

2.5 ug/ml

Immunohistochemistry-Paraffin

2.5 ug/ml

Western Blot

0.5-1 ug/ml

Formulation, Preparation, and Storage

Purification

Protein A purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Calpain 6

Calpains make up a ubiquitously expressed, well-conserved family of calcium-dependent cysteine proteases. The calpain proteins are heterodimers consisting of an invariant small subunit and variable large subunits. This large subunit possesses a cysteine protease domain, and both subunits possess calcium-binding domains. Calpains have been implicated in neurodegenerative processes as their activation can be triggered by calcium influx and oxidative stress. Calpain 6 (CAPN6) is most similar to Calpain 5; the C-terminal region of CAPN6 lacks homology to the calmodulin-like domain of other vertebrate calpains. CAPN6 is thought to be involved in the regulation of microtubule dynamics and cytoskeletal organization. CAPN6 has also been recently identified as an HIV dependency factor (HDF), suggesting that CAPN6 may be an important drug target in HIV treatment.

Alternate Names

calpain 6, calpain-6, Calpain-like protease X-linked, Calpamodulin, CalpMCALPM, CANPXcalpamodulin, CAPNX, DJ914P14.1, EC 3.4.22

Gene Symbol

CAPN6

UniProt

NP_055104 (Human)

Additional Calpain 6 Products

Product Documents for Calpain 6 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Download SDS

Product Specific Notices for Calpain 6 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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