Calsyntenin-1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-17025

Novus Biologicals, part of Bio-Techne
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NBP3-17025-100ul
NBP3-17025-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Predicted:

Rat (91%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Calsyntenin-1 Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: TITREVEPEGDGAEDPTVQESLVSEEIVHDLDTCEVTVEGEELNHEQESLEVDMARLQQKGIEVSSSELGMTFTGVDTMASYEEVLHLLRYRNWHARSLLDRKFKL

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Calsyntenin-1 Antibody

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025] - Analysis in human cerebral cortex and liver tissues using Anti-CLSTN1 antibody. Corresponding CLSTN1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025] - Staining of human cerebral cortex shows high expression.
Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025]

Immunohistochemistry-Paraffin: Calsyntenin-1 Antibody [NBP3-17025] - Staining of human liver shows low expression as expected.

Applications for Calsyntenin-1 Antibody

Application
Recommended Usage

Immunohistochemistry

1:200 - 1:500

Immunohistochemistry-Paraffin

1:200 - 1:500
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.2, 40% glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Calsyntenin-1

CLSTN1 (calsyntenin 1) is mainly expressed in brain tissues and to a lesser degree in heart, skeletal muscle and the placenta. It accumulates in dystrophic neurites around the amyloid core of Alzheimer disease senile plaques. The protein induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport. It is involved in complex formation with APBA2 and APP, stabilizing APP metabolism and enhancing APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation. It may also modulate calcium-mediated postsynaptic signals.

Alternate Names

Alcadein-alpha, Calsyntenin1, CLSTN1, CS1, CSTN1, XB31alpha

Gene Symbol

CLSTN1

Additional Calsyntenin-1 Products

Product Documents for Calsyntenin-1 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Calsyntenin-1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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