Caspase-12 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-24518

Novus Biologicals, part of Bio-Techne
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NBP2-24518
NBP2-24518SS
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Key Product Details

Species Reactivity

Validated:

Mouse

Predicted:

Rat (94%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all Caspase-12 Antibodies »

Product Specifications

Immunogen

Within the range of amino acids 100-131 of mouse Caspase-12 was used as the immunogen.

Reactivity Notes

The amino acid sequence used as immunogen is 100% homologous in mouse and 94% homologous in rat.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Caspase-12 Antibody

Western Blot: Caspase-12 Antibody [NBP2-24518]

Western Blot: Caspase-12 Antibody [NBP2-24518]

Western Blot: Caspase-12 Antibody [NBP2-24518] - Analysis of Caspase-12 in mouse skeletal muscle lysate in the 1) absence and 2) presence of immunizing peptide using this antibody. 25 ug/ml. I goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for Caspase-12 Antibody

Application
Recommended Usage

Western Blot

0.25-1 ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspase-12

Caspases are cysteine proteases that cleave C-terminal aspartic acid residues on their substrate molecules. This gene, CASP12, is most highly related to members of the ICE subfamily of caspases that process inflammatory cytokines. In rodents, the homolog of this gene mediates apoptosis in response to endoplasmic reticulum stress. However, in humans this gene contains a polymorphism for the presence or absence of a premature stop codon. The majority of human individuals have the premature stop codon and produce a truncated non-functional protein. The read-through codon occurs primarily in individuals of African descent and carriers have endotoxin hypo-responsiveness and an increased susceptibility to severe sepsis. (provided by RefSeq)

Alternate Names

CASP12, Caspase12

Gene Symbol

CASP12

UniProt

O08736

Additional Caspase-12 Products

Product Documents for Caspase-12 Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Caspase-12 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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