Caspr1 Antibody (SR1234)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21789

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21789-100ul
NBP3-21789-50ul
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Key Product Details

Species Reactivity

Validated:

Human, Mouse, Rat

Applications

Immunohistochemistry, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1234

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Caspr1 Antibodies »

Product Summary for Caspr1 Antibody (SR1234)

Immunogen

A synthesized peptide derived from human Caspr1 (Uniprot #: P78357)

Specificity

Detects endogenous levels of total Caspr1

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

165 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Caspr1 Antibody (SR1234)

Western Blot: Caspr1 Antibody (SR1234) [NBP3-21789] -

Western Blot: Caspr1 Antibody (SR1234) [NBP3-21789] - Western blot analysis using NBP3-21789 in U87-MG cell lysate.

Applications for Caspr1 Antibody (SR1234)

Application
Recommended Usage

Immunohistochemistry

1:50-1:200

Western Blot

1:500-1:2000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspr1

Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. It is required for junction formation and ion channel localization and plays an important role in the propagation of saltatory nerve conduction. Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. Caspr1 is proteolytically cleaved by Reelin, and this action is inhibited by the cellular prion protein (PrP). The ECD contains one Factor 5/8-like domain, four Laminin-G-like domains, two EGF-like domains, and one Fibrinogen-like domain.

Long Name

Contactin Associated Protein-like 1

Alternate Names

CNTNAP, CNTNAP1, p190

Gene Symbol

CNTNAP1

Additional Caspr1 Products

Product Documents for Caspr1 Antibody (SR1234)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Caspr1 Antibody (SR1234)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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