Caspr1 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-13184

Novus Biologicals, part of Bio-Techne
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NBP3-13184
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Key Product Details

Species Reactivity

Validated:

Mouse, Rat

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Caspr1 Antibodies »

Product Summary for Caspr1 Antibody

Immunogen

Recombinant protein encompassing a sequence within the C-terminus region of mouse Caspr1. The exact sequence is proprietary.

Reactivity Notes

Rhesus Monkey (83%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Description

Centrifuge briefly prior to opening.

Scientific Data Images for Caspr1 Antibody

Western Blot: Caspr1 Antibody [NBP3-13184]

Western Blot: Caspr1 Antibody [NBP3-13184]

Western Blot: Caspr1 Antibody [NBP3-13184] - Various tissue extracts (75 ug) were separated by 5% SDS-PAGE, and the membrane was blotted with Caspr1 antibody (NBP3-13184) diluted at 1:1000.
Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP3-13184]

Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP3-13184]

Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP3-13184] - Caspr1 antibody detects Caspr1 protein at cell membrane and cytoplasm in rat brain by immunohistochemical analysis. Sample: Paraffin-embedded rat brain. Caspr1 antibody (NBP3-13184) diluted at 1:1000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min
Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP3-13184]

Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP3-13184]

Immunohistochemistry-Paraffin: Caspr1 Antibody [NBP3-13184] - Caspr1 antibody detects Caspr1 protein at cell membrane and cytoplasm in mouse brain by immunohistochemical analysis. Sample: Paraffin-embedded mouse brain. Caspr1 antibody (NBP3-13184) diluted at 1:1000. Antigen Retrieval: Citrate buffer, pH 6.0, 15 min

Applications for Caspr1 Antibody

Application
Recommended Usage

Immunohistochemistry

Optimal dilutions of this antibody should be experimentally determined.

Immunohistochemistry-Paraffin

Optimal dilutions of this antibody should be experimentally determined.

Western Blot

Optimal dilutions of this antibody should be experimentally determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Antigen Affinity-purified

Formulation

PBS (pH 7), 20% Glycerol

Preservative

0.025% Proclin 300

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Caspr1

Contactin-associated protein 1 (Caspr1), also known as Neurexin-4, Paranodin, and NCP1, is an approximately 190 kDa transmembrane protein that is concentrated at paranodal junctions of axons during myelination. It is required for junction formation and ion channel localization and plays an important role in the propagation of saltatory nerve conduction. Caspr1 interacts with Contactins and Nogo-A at the paranodal junction and inhibits the binding of Contactin to glial cell Neurofascin. Caspr1 is proteolytically cleaved by Reelin, and this action is inhibited by the cellular prion protein (PrP). The ECD contains one Factor 5/8-like domain, four Laminin-G-like domains, two EGF-like domains, and one Fibrinogen-like domain.

Long Name

Contactin Associated Protein-like 1

Alternate Names

CNTNAP, CNTNAP1, p190

Gene Symbol

CNTNAP1

Additional Caspr1 Products

Product Documents for Caspr1 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Caspr1 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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