Cathepsin C/DPPI Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-55936

Novus Biologicals, part of Bio-Techne
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NBP2-55936
NBP2-55936-25ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Cathepsin C/DPPI Antibodies »

Product Summary for Cathepsin C/DPPI Antibody

Immunogen

This antibody was developed against a recombinant protein corresponding to the following amino acid sequence: SQEKYSNRLYKYDHNFVKAINAIQKSWTATTYMEYETLTLGDMIRRSGGHSRKIPRPKPAPLT

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Cathepsin C/DPPI Antibody

Immunocytochemistry/ Immunofluorescence: Cathepsin C/DPPI Antibody [NBP2-55936]

Immunocytochemistry/ Immunofluorescence: Cathepsin C/DPPI Antibody [NBP2-55936]

Immunocytochemistry/Immunofluorescence: Cathepsin C/DPPI Antibody [NBP2-55936] - Staining of human cell line U-251 MG shows localization to vesicles. Antibody staining is shown in green.

Applications for Cathepsin C/DPPI Antibody

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

0.25-2 ug/ml
Application Notes
ICC/IF Fixation Permeabilization: Use PFA/Triton X-100.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Cathepsin C/DPPI

DPP1 is encoded by this gene, a member of the peptidase C1 family, is a lysosomal cysteine proteinase that appears to be a central coordinator for activation of many serine proteinases in immune/inflammatory cells. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor, and a residual portion of the propeptide acts as an intramolecular chaperone for the folding and stabilization of the mature enzyme. This enzyme requires chloride ions for activity and can degrade glucagon. Defects in the encoded protein have been shown to be a cause of Papillon-Lefevre syndrome, an autosomal recessive disorder characterized by palmoplantar keratosis and periodontitis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq]

Alternate Names

CTSC, DPPI, PALS, PLS

Gene Symbol

CTSC

Additional Cathepsin C/DPPI Products

Product Documents for Cathepsin C/DPPI Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cathepsin C/DPPI Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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