Cav1.2 Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-20896

Novus Biologicals, part of Bio-Techne
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NBP1-20896
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Key Product Details

Species Reactivity

Human

Applications

Peptide ELISA, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Goat IgG

Concentration

0.5 mg/ml

View all Cav1.2 Antibodies »

Product Specifications

Immunogen

Peptide with sequence C-RARGRPSEEELQD, from the C Terminus of the protein sequence according to NP_000710.5; NP_955630.2; NP_001161097.1; NP_001123299.1; NP_001123301.1; NP_001161096.1; NP_001123302.1; NP_001123303.1 and more.

Epitope

C terminus

Specificity

This antibody is expected to recognise all reported human isoforms.

Clonality

Polyclonal

Host

Goat

Isotype

IgG

Scientific Data Images for Cav1.2 Antibody

Western Blot: Cav1.2 Antibody [NBP1-20896]

Western Blot: Cav1.2 Antibody [NBP1-20896]

Western Blot: Cav1.2 Antibody [NBP1-20896] - (1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Applications for Cav1.2 Antibody

Application
Recommended Usage

Peptide ELISA

Detection limit 1:64000

Western Blot

1:100-1:2000
Application Notes
Approx. 200kDa band observed in Human Heart lysate (calculated MW of 240kDa according to NP_000710.5).
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA

Preservative

0.02% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at -20C. Avoid freeze-thaw cycles.

Background: Cav1.2

This gene encodes an alpha-1 subunit of a voltage-dependent calcium channel. Calcium channels mediate the influx of calcium ions into the cell upon membrane polarization. The alpha-1 subunit consists of 24 transmembrane segments and forms the pore through which ions pass into the cell. The calcium channel consists of a complex of alpha-1, alpha-2/delta, beta, and gamma subunits in a 1:1:1:1 ratio. There are multiple isoforms of each of these proteins, either encoded by different genes or the result of alternative splicing of transcripts. The protein encoded by this gene binds to and is inhibited by dihydropyridine. Alternative splicing results in many transcript variants encoding different proteins.

Long Name

Voltage-dependent L-type calcium channel subunit alpha-1C

Alternate Names

CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1

Entrez Gene IDs

775 (Human)

Gene Symbol

CACNA1C

UniProt

NP_000710.5 (Human)

Additional Cav1.2 Products

Product Documents for Cav1.2 Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Cav1.2 Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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