Cav3.2 Antibody - BSA Free

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-41303

Novus Biologicals, part of Bio-Techne

Key Product Details

Species Reactivity

Human, Mouse, Rat

Applications

ELISA, Immunocytochemistry/ Immunofluorescence, Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Format

BSA Free

Concentration

1 mg/ml

View all Cav3.2 Antibodies »

Product Specifications

Immunogen

Antibody was raised against a 16 amino acid peptide near the center of human CACNA1H. The immunogen is located within amino acids 1010 - 1060 of CACNA1H. Amino Acid Squence: AEGDANRSDTDEDKTS

Specificity

Multiple isoforms of CACNA1H are known to exist.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

260 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Cav3.2 Antibody - BSA Free

Western Blot: Cav3.2 AntibodyBSA Free [NBP2-41303]

Western Blot: Cav3.2 AntibodyBSA Free [NBP2-41303]

Western Blot: Cav3.2 Antibody [NBP2-41303] - Analysis of CACNA1H in 293 cell lysate with CACNA1H antibody at 1 ug/ml in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry-Paraffin: Cav3.2 Antibody - BSA Free [NBP2-41303]

Immunohistochemistry-Paraffin: Cav3.2 Antibody - BSA Free [NBP2-41303]

Immunohistochemistry-Paraffin: Cav3.2 Antibody [NBP2-41303] - Cav3.2 in mouse brain tissue withCav3.2 antibody at 5 ug/ml.

Immunohistochemistry: Cav3.2 Antibody [NBP2-41303] -

Immunohistochemistry: Cav3.2 Antibody [NBP2-41303] - Cav3.2 in mouse brain tissue with Cav3.2 antibody at 20 ug/ml.
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Applications for Cav3.2 Antibody - BSA Free

Application
Recommended Usage

Immunocytochemistry/ Immunofluorescence

20 ug/mL

Immunohistochemistry

5 ug/ml

Immunohistochemistry-Paraffin

5 ug/ml

Western Blot

1 - 2 ug/ml

Formulation, Preparation, and Storage

Purification

Peptide affinity purified

Formulation

PBS

Format

BSA Free

Preservative

0.02% Sodium Azide

Concentration

1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Cav3.2

Ion channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient (1). They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces. There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligandgated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inwardrectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels (2). Specifically, Cav3.2 is a protein which in humans is encoded by the CACNA1H gene. Studies suggest certain mutations in this gene lead to childhood absence epilepsy (3, 4). Studies also suggest that the up-regulations of Cav3.2 may participate in the progression of prostate cancer toward an androgen-independent stage (5).

Long Name

Voltage-dependent T-type calcium channel subunit alpha-1H

Alternate Names

CACNA1H, CACNA1HB

Gene Symbol

CACNA1H

Additional Cav3.2 Products

Product Documents for Cav3.2 Antibody - BSA Free

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Cav3.2 Antibody - BSA Free

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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