CD46 Antibody (122.2)

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-25222

Clone 122.2 was used by HLDA to establish CD designation.
Novus Biologicals, part of Bio-Techne
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NBP2-25222
NBP2-25222-0.02mg
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Flow Cytometry, Immunocytochemistry/ Immunofluorescence, Immunofluorescence

Label

Unconjugated

Antibody Source

Monoclonal Mouse IgG1 kappa Clone # 122.2

Concentration

0.2 mg/ml

View all CD46 Antibodies »

Product Summary for CD46 Antibody (122.2)

Immunogen

Recombinant human CD46 protein (Uniprot: P15529)

Localization

Cell surface

Marker

T-Cell Marker

Clonality

Monoclonal

Host

Mouse

Isotype

IgG1 kappa

Description

200ug/ml of antibody purified from Bioreactor Concentrate by Protein A or G. Prepared in 10 mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0 mg/ml. (NBP2-33159)

Antibody with azide - store at 2 to 8C. Antibody without azide - store at -20 to -80C.

Scientific Data Images for CD46 Antibody (122.2)

Flow Cytometry: CD46 Antibody (122.2) [NBP2-25222]

Flow Cytometry: CD46 Antibody (122.2) [NBP2-25222]

Flow Cytometry: CD46 Antibody (122.2) [NBP2-25222] - FCM staining of human PBMCs using CD46 Antibody (122.2).

Applications for CD46 Antibody (122.2)

Application
Recommended Usage

Flow Cytometry

1-2 ug/million cells

Immunocytochemistry/ Immunofluorescence

1-2 ug/ml

Immunofluorescence

0.5-1ug/ml
Application Notes
Optimal dilution for a specific application should be determined.
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

10 mM PBS with 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.2 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: CD46

CD46 acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. It may be involved in the fusion of the spermatozoa with the oocyte during fertilization. CD46 acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.

Alternate Names

CD46, MCP

Gene Symbol

CD46

UniProt

NP_002380, P15529 (Human)

Additional CD46 Products

Product Documents for CD46 Antibody (122.2)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for CD46 Antibody (122.2)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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