Claudin-4 Antibody (SR1284)

Novus Biologicals, part of Bio-Techne | Catalog # NBP3-21843

Recombinant Monoclonal Antibody
Novus Biologicals, part of Bio-Techne
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NBP3-21843-100ul
NBP3-21843-50ul
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Key Product Details

Species Reactivity

Validated:

Human

Applications

Immunohistochemistry, Immunoprecipitation, Western Blot

Label

Unconjugated

Antibody Source

Recombinant Monoclonal Rabbit IgG Clone # SR1284

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

View all Claudin-4 Antibodies »

Product Summary for Claudin-4 Antibody (SR1284)

Immunogen

A synthesized peptide derived from human Claudin-4 (Uniprot #: O14493)

Specificity

Detects endogenous levels of total Claudin-4

Clonality

Monoclonal

Host

Rabbit

Isotype

IgG

Theoretical MW

18 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Scientific Data Images for Claudin-4 Antibody (SR1284)

Western Blot: Claudin-4 Antibody (SR1284) [NBP3-21843] -

Western Blot: Claudin-4 Antibody (SR1284) [NBP3-21843] - Western blot analysis using NBP3-21843 in MCF7 cell lysate.

Applications for Claudin-4 Antibody (SR1284)

Application
Recommended Usage

Immunohistochemistry

1:100-1:500

Immunoprecipitation

1:20

Western Blot

1:500-1:1000
Please Note: Optimal dilutions of this antibody should be experimentally determined.

Formulation, Preparation, and Storage

Purification

Affinity purified

Formulation

PBS, pH 7.4, 150mM NaCl, 50% glycerol.

Preservative

0.02% Sodium Azide

Concentration

Please see the vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Claudin-4

The Claudin superfamily consists of many structurally related proteins in humans. These proteins are important structural and functional components of tight junctions in paracellular transport. Claudins are located in both epithelial and endothelial cells in all tight junction-bearing tissues. Three classes of proteins are known to localize to tight junctions, including the Claudins, Occludin and junction adhesion molecule (JAM). Claudins, which consist of four transmembrane domains and two extracellular loops, make up tight junction strands. Claudin expression is highly restricted to specific regions of different tissues and variations of Claudin expression may have an important role in transcellular transport through tight junctions. In rat liver, claudin-3 is uniformly expressed, whereas in the pancreas, claudin-3 is expressed in junctions of the duct epithelia and junctions of acinar cells. Claudin-3 binds the peptide toxin Clostridium perfringens enterotoxin (CPE) at the cell surface via the second extracellular loop of claudin-3. The gene encoding human claudin-3 maps to chromosome 7q11.23.

Alternate Names

Claudin4, CLDN4, CPE-R, CPETR1, WBSCR8

Gene Symbol

CLDN4

Additional Claudin-4 Products

Product Documents for Claudin-4 Antibody (SR1284)

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Claudin-4 Antibody (SR1284)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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