CLEC4E Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-27093

Novus Biologicals, part of Bio-Techne
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NBP2-27093
NBP2-27093SS
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Key Product Details

Species Reactivity

Validated:

Human, Primate

Predicted:

Rhesus Macaque (94%), Sheep (94%). Backed by our 100% Guarantee.

Applications

Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

0.5 mg/ml

View all CLEC4E Antibodies »

Product Specifications

Immunogen

This antibody was raised against CLEC4E

Reactivity Notes

Cow (75%), rat (68%), panda (74%), dog (71%), horse (75%), and African bush elephant (65%), mouse, and rabbit (67%).

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for CLEC4E Antibody

Western Blot: CLEC4E Antibody [NBP2-27093]

Western Blot: CLEC4E Antibody [NBP2-27093]

Western Blot: CLEC4E Antibody [NBP2-27093] - Analysis of CLEC4E using NBP2-27093. Human spleen cell lysate in the 1) absence and 2) presence of immunizing peptide, 3) mouse spleen, 4) rat spleen, 5) Ramos and 6) THP1 cell lysate probed with 2 ug/ml of CLEC4E antibody. Goat anti-rabbit Ig HRP secondary antibody and PicoTect ECL substrate solution were used for this test.

Applications for CLEC4E Antibody

Application
Recommended Usage

Western Blot

2-4ug/ml

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

0.2 ml PBS and 0.05% BSA

Preservative

0.05% Sodium Azide

Concentration

0.5 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: CLEC4E

A member of the C-type lectin superfamily, CLEC4E, also known as Mincle, is a ~25kDa protein. CLEC4E is expressed and found on the surface of activated macrophages. CLEC4E has also been associated with expression on innate effector cells such as dendritic cells. It serves as a receptor for pathogenic fungi such as Malassezia which causes atopic dermatitis, tinea versicolor or acute sepsis reactions. CLEC4E also serves as a sensor of damaged cells. Shown to be associated with FcRfx chain, CLEC4E also may be associated with TLR since Mincle-/- mice have above background cytokine production. CLEC4E specific antibody enables more in-depth analysis of mechanism of action, signaling pathways and development of therapies and drugs which are Mincle (CLEC4E) associated. CLEC4E is an innate immune receptor, a PAMP sensor involved in inflammatory response activation pathways.

Long Name

C-type Lectin Domain Family 4, Member E

Alternate Names

CLECSF9, MINCLE

Gene Symbol

CLEC4E

UniProt

Q9ULY5

Additional CLEC4E Products

Product Documents for CLEC4E Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for CLEC4E Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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