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Collagen I/III Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NB100-64523

Novus Biologicals, part of Bio-Techne
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NB100-64523-0.05ml

Key Product Details

Species Reactivity

Bovine

Applications

ELISA, Immunocytochemistry/ Immunofluorescence

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

1.0 mg/ml

Product Specifications

Immunogen

Bovine collagen type I and III from skin

Reactivity Notes

Cross reacts with Bovine.

Specificity

NB100-64523 reacts with both Collagen I and III. Less than 0.5% reactivity was observed with bovine albumin and immunoglobulins. Collagen is located in the extracellular matrix of connective tissues. It is part of the interacting network of proteoglycans and proteins that provides a structural framework for both soft and calcified connective tissues.

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Applications for Collagen I/III Antibody

Application
Recommended Usage

ELISA

1:100-1:2000

Immunocytochemistry/ Immunofluorescence

1:10-1:40

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS

Preservative

1% Dextran, 1% Mannitol

Concentration

1.0 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Collagen I/III

Collagens are highly conserved throughout evolution and are characterized by an uninterrupted "Glycine X Y" triplet repeat that is a necessary part of the triple helical structure. Type I collagen (95 kDa) is found in bone, cornea, skin and tendon. Mutations in the encoding gene are associated with osteogenesis imperfecta, Ehlers Danlos syndrome, and idiopathic osteoporosis. Reciprocal translocations between chromosomes 17 and 22, where this gene and the gene for Platelet-derived growth factor beta are located, are associated with a particular type of skin tumor called dermatofibrosarcoma protuberans, resulting from unregulated expression of the growth factor.

Alternate Names

Alpha-1 type I collagen, Collagen 1/3, collagen alpha 1 chain type I, collagen alpha-1(I) chain, collagen of skin, tendon and bone, alpha-1 chain, collagen, type I, alpha 1, OI4, pro-alpha-1 collagen type 1

Entrez Gene IDs

282187 (Bovine)

Gene Symbol

COL1A1

UniProt

Additional Collagen I/III Products

Product Documents for Collagen I/III Antibody

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

Product Specific Notices for Collagen I/III Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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