Collagen XVII Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-91800

Novus Biologicals, part of Bio-Techne
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NBP1-91800
NBP1-91800-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Validated:

Human

Predicted:

Mouse (92%), Rat (92%). Backed by our 100% Guarantee.

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin, Western Blot

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Collagen XVII Antibodies »

Product Specifications

Immunogen

This antibody was developed against Recombinant Protein corresponding to amino acids: DGTEVTERIVTETVTTRLTSLPPKGGTSNGYAKTASLGGGSRLEKQSLTHGSSGYINSTGSTRGHASTSSYRRAHSPASTLPNSPGSTFERKTHVTR

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Collagen XVII Antibody

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP1-91800]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP1-91800]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP1-91800] - Analysis in human skin and liver tissues. Corresponding COL17A1 RNA-seq data are represented for the same tissues.
Western Blot: Collagen XVII Antibody [NBP1-91800]

Western Blot: Collagen XVII Antibody [NBP1-91800]

Western Blot: Collagen XVII Antibody [NBP1-91800] - Analysis in human cell lines A-431 and MCF-7 using anti-COL17A1 antibody. Corresponding COL17A1 RNA-seq data are presented for the same cell lines. Loading control: anti-GAPDH.
Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP1-91800]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP1-91800]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP1-91800] - Staining of human pancreas shows no positivity in exocrine glandular cells as expected.
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Applications for Collagen XVII Antibody

Application
Recommended Usage

Immunohistochemistry

1:500 - 1:1000

Immunohistochemistry-Paraffin

1:500-1:1000

Western Blot

0.04-0.4 ug/ml
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Collagen XVII

Collagen XVII encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Long Name

Collagen Type XVII Alpha 1

Alternate Names

BP180, BPA-2, BPAG2, COL17A1, ERED, LAD-1

Gene Symbol

COL17A1

Additional Collagen XVII Products

Product Documents for Collagen XVII Antibody

Product Datasheets

Certificate of Analysis

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Product Specific Notices for Collagen XVII Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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