Collagen XVII Antibody

Novus Biologicals, part of Bio-Techne | Catalog # NBP2-38686

Novus Biologicals, part of Bio-Techne
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NBP2-38686
NBP2-38686-25ul
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Key Product Details

Validated by

Orthogonal Validation

Species Reactivity

Human

Applications

Immunohistochemistry, Immunohistochemistry-Paraffin

Label

Unconjugated

Antibody Source

Polyclonal Rabbit IgG

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

View all Collagen XVII Antibodies »

Product Specifications

Immunogen

This antibody was developed against a recombinant protein corresponding to amino acids: NLPSHVWSSTLPAGSSMGTYHNNMTTQSSSLLNTNAYSAGSVFGVPNNMASCSPTLHPGLSTSSSVFGMQNNLAPSLTTLSHGTTTTSTA

Reactivity Notes

Immunogen displays the following percentage of sequence identity for non-tested species: Mouse (83%), Rat (84%)

Clonality

Polyclonal

Host

Rabbit

Isotype

IgG

Scientific Data Images for Collagen XVII Antibody

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686] - Analysis in human skin and liver tissues using NBP2-38686 antibody. Corresponding COL17A1 RNA-seq data are presented for the same tissues.
Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686] - Staining of human Skeletal muscle shows no positivity in myocytes as expected.
Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686]

Immunohistochemistry-Paraffin: Collagen XVII Antibody [NBP2-38686] - Staining of human Cerebral cortex shows no positivity in neuronal cells as expected.
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Applications for Collagen XVII Antibody

Application
Recommended Usage

Immunohistochemistry

1:20 - 1:50

Immunohistochemistry-Paraffin

1:20 - 1:50
Application Notes
For IHC-Paraffin, HIER pH 6 retrieval is recommended.

Formulation, Preparation, and Storage

Purification

Immunogen affinity purified

Formulation

PBS (pH 7.2) and 40% Glycerol

Preservative

0.02% Sodium Azide

Concentration

Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

Background: Collagen XVII

Collagen XVII encodes the alpha chain of type XVII collagen. Unlike most collagens, collagen XVII is a transmembrane protein. Collagen XVII is a structural component of hemidesmosomes, multiprotein complexes at the dermal-epidermal basement membrane zone that mediate adhesion of keratinocytes to the underlying membrane. Mutations in this gene are associated with both generalized atrophic benign and junctional epidermolysis bullosa. Two homotrimeric forms of type XVII collagen exist. The full length form is the transmembrane protein. A soluble form, referred to as either ectodomain or LAD-1, is generated by proteolytic processing of the full length form. [provided by RefSeq]. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Long Name

Collagen Type XVII Alpha 1

Alternate Names

BP180, BPA-2, BPAG2, COL17A1, ERED, LAD-1

Gene Symbol

COL17A1

UniProt

Q9UMD9 (Human)

Additional Collagen XVII Products

Product Documents for Collagen XVII Antibody

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Collagen XVII Antibody

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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