Complement C3c Antibody (4)

Novus Biologicals, part of Bio-Techne | Catalog # NBP1-49651

Novus Biologicals, part of Bio-Techne
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NBP1-49651
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Key Product Details

Species Reactivity

Human

Applications

Immunoprecipitation

Label

Unconjugated

Antibody Source

Monoclonal Rat IgG2A Clone # 4

Concentration

0.1 mg/ml

View all Complement C3c Antibodies »

Product Specifications

Immunogen

The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.

Clonality

Monoclonal

Host

Rat

Isotype

IgG2A

Applications for Complement C3c Antibody (4)

Application
Recommended Usage

Immunoprecipitation

1:10-1:500

Formulation, Preparation, and Storage

Purification

Protein A or G purified

Formulation

PBS with 1% BSA

Preservative

0.02% Sodium Azide

Concentration

0.1 mg/ml

Shipping

The product is shipped with polar packs. Upon receipt, store it immediately at the temperature recommended below.

Stability & Storage

Store at 4C.

Background: Complement C3c

The monoclonal antibody 4 recognizes the cleaved human C3 fragment C3c. The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/ml. An inherited deficiency of C3 predisposes the person to frequent bacterial infections. C3 fragments are deposited in tissues at sites of antibody-mediated immunopathology. In ulcerative colitis and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by C3-convertases results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b and C3f. iC3b is further processed into C3c and C3dg. The monoclonal antibody 4 recognizes a conformational epitope in C3c, C3b and iC3b.

Alternate Names

AHUS5, ARMD9, ASP, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, complement C3, complement component 3, complement component C3, CPAMD1acylation-stimulating protein cleavage product

Gene Symbol

C3

Additional Complement C3c Products

Product Documents for Complement C3c Antibody (4)

Product Datasheets

Certificate of Analysis

To download a Certificate of Analysis, please enter a lot number in the search box below.

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Product Specific Notices for Complement C3c Antibody (4)

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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